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Fair value of financial instruments and marketable securities - Hierarchy (Details) - USD ($) $ in Thousands	Jun. 30, 2021	Dec. 31, 2020
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities - available for sale	$ 569,040	$ 894,838
Marketable securities - equity investments	24,700	20,500
ClearPoint convertible debt security	33,600	29,300
Contingent consideration payable	241,200	240,400
Recurring basis
Financial assets and liabilities measured at fair value on recurring basis
ClearPoint Equity Investments	24,713	20,503
ClearPoint convertible debt security	33,578	29,252
Recurring basis | Level 1
Financial assets and liabilities measured at fair value on recurring basis
ClearPoint Equity Investments	24,713	20,503
Recurring basis | Level 2
Financial assets and liabilities measured at fair value on recurring basis
ClearPoint convertible debt security	33,578	29,252
Recurring basis | Development and Regulatory Milestone
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	139,600	139,200
Recurring basis | Development and Regulatory Milestone | Level 3
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	139,600	139,200
Recurring basis | Net Sales Milestones and Royalties
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	101,600	101,200
Recurring basis | Net Sales Milestones and Royalties | Level 3
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	101,600	101,200
Recurring basis | Marketable securities
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities - available for sale	569,040	894,838
Marketable securities - equity investments	200,694
Recurring basis | Marketable securities | Level 1
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities - equity investments	200,694
Recurring basis | Marketable securities | Level 2
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities - available for sale	$ 569,040	$ 894,838

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