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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Dec. 31, 2020
Jun. 30, 2016
May 31, 2013
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
May 31, 2021
Jan. 31, 2020
Stock option plan                  
Share-based compensation expense       $ 25,699 $ 16,910 $ 51,406 $ 32,130    
Restricted stock                  
Stock option plan                  
Grants in period (in shares)           951,558      
Stock option                  
Stock option plan                  
Granted (in shares)           2,282,914      
Expected dividend yield (as a percent)           0.00%      
Weighted average grant date fair value (in dollars per share)           $ 44.66      
Expected term (in years)           5 years 6 months      
Stock option | Maximum                  
Stock option plan                  
Risk-free interest rate (as a percent)           0.96%      
Expected volatility (as a percent)           88.61%      
Stock option | Minimum                  
Stock option plan                  
Risk-free interest rate (as a percent)           0.51%      
Expected volatility (as a percent)           85.94%      
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock                  
Stock option plan                  
Number of shares available for issuance       0   0      
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock | Maximum                  
Stock option plan                  
Number of shares subject to outstanding awards (in shares)     3,040,444            
2009 Equity and Long Term Incentive Plan and 2013 Stock Incentive Plan | Common stock                  
Stock option plan                  
Number of shares available for issuance     122,296            
2013 Long Term Incentive Plan | Minimum                  
Stock option plan                  
Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase Number     2,500,000            
Annual increase in the number of shares outstanding on the first day of the fiscal year     4.00%            
2013 Long Term Incentive Plan | Common stock                  
Stock option plan                  
Number of shares available for issuance       849,277   849,277      
2020 Inducement Stock Incentive Plan | Common stock                  
Stock option plan                  
Number of shares available for issuance       960,033   960,033      
Number of additional shares authorized (in shares) 1,000,000                
2020 Inducement Stock Incentive Plan | Common stock | Maximum                  
Stock option plan                  
Number of shares authorized (in shares)                 1,000,000
2020 Inducement Stock Incentive Plan | Stock option                  
Stock option plan                  
Inducement grants for non-statutory stock options (in shares)           206,025      
2020 Inducement Stock Incentive Plan | Restricted stock units                  
Stock option plan                  
Grants in period (in shares)           68,540      
Employee Stock Purchase Plan                  
Stock option plan                  
Number of shares authorized (in shares)       2,000,000   2,000,000   1,000,000  
Share-based compensation expense       $ 700   $ 1,200      
Award requisite service period   6 months              
Purchase price of common stock, percent   85.00%              
Employee stock purchase plan, voting percentage limit   5.00%