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Revenue recognition - Narrative (Details) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended
	Mar. 31, 2021 USD ($)	Jun. 30, 2021 USD ($) Distributor	Jun. 30, 2020 USD ($) Distributor	Jun. 30, 2021 USD ($) segment Distributor	Jun. 30, 2020 USD ($) Distributor	Dec. 31, 2020 USD ($)	Nov. 30, 2011 USD ($)
Collaboration and royalty revenue
Number of operating segments | segment				1
Number of distributors | Distributor		2	2	2	3
Contract with Customer, Liability						$ 4,200
Performance obligations satisfied in period		$ 1,900	$ 2,000	$ 4,000	$ 4,000
Remaining potential milestones that can be achieved		335,000		335,000
Revenue		116,676	75,239	234,620	143,498
United States
Collaboration and royalty revenue
Net product revenue		49,100	36,200	92,700	63,600
Non-US
Collaboration and royalty revenue
Net product revenue		$ 54,000	$ 39,000	$ 101,700	$ 79,800
Minimum
Collaboration and royalty revenue
Percentage of net product sales threshold		10.00%	10.00%	10.00%	10.00%
Collaboration revenue
Collaboration and royalty revenue
Revenue		$ 0	$ 0	$ 20,007	$ 63
Royalty revenue
Collaboration and royalty revenue
Revenue		13,563	0	20,220
SMA License Agreement | Collaboration revenue
Collaboration and royalty revenue
Revenue		0	0	20,000	100
SMA License Agreement | Royalty revenue
Collaboration and royalty revenue
Revenue		13,600	0	20,200	0
SMA License Agreement | Roche And SMA Foundation | Collaboration revenue
Collaboration and royalty revenue
Revenue		0	$ 0	20,000	100
Research And Development Event Milestones | SMA License Agreement
Collaboration and royalty revenue
Remaining potential milestones that can be achieved		10,000		10,000
Research And Development Event Milestones | SMA License Agreement | Maximum
Collaboration and royalty revenue
Remaining potential milestones that can be achieved							$ 135,000
Sales Milestones | SMA License Agreement
Collaboration and royalty revenue
Remaining potential milestones that can be achieved		325,000		325,000
Milestone payments received	$ 20,000	$ 0		$ 20,000	$ 0
Sales Milestones | SMA License Agreement | Maximum
Collaboration and royalty revenue
Remaining potential milestones that can be achieved							$ 325,000

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