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Intangible assets and goodwill - Narrative (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended 34 Months Ended
Apr. 20, 2017
Dec. 31, 2019
May 31, 2019
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2019
Jun. 30, 2021
Dec. 31, 2020
Aug. 23, 2018
Finite-Lived Intangible Assets                      
Amortization of acquired intangible assets       $ 12,751 $ 8,731 $ 24,028 $ 16,679        
Total allocation of IPR&D assets           576,500          
Change in indefinite-lived intangibles                 $ 0    
Goodwill       82,341   82,341     82,341 $ 82,341 $ 82,300
Changes in goodwill       0   $ 0          
Weighted Average                      
Finite-Lived Intangible Assets                      
Remaining amortization period           2 years 10 months 24 days          
Agilis Merger Agreement | Akcea                      
Finite-Lived Intangible Assets                      
Milestone payments   $ 4,000 $ 6,000     $ 4,000   $ 6,000      
Useful life   10 years 10 years                
Emflaza asset acquisition                      
Finite-Lived Intangible Assets                      
Finite-lived intangibles $ 148,400                    
Milestone obligation payments recorded       17,100 $ 12,200 26,000 $ 15,000        
Useful life 7 years                    
Emflaza asset acquisition | Accounts payable and accrued expenses                      
Finite-Lived Intangible Assets                      
Milestone payable       $ 18,400   $ 18,400     $ 18,400