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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Common stock
Additional paid-in capital
Cumulative Effect Adjustment
Additional paid-in capital
Accumulated other comprehensive income (loss)
Accumulated deficit
Cumulative Effect Adjustment
Accumulated deficit
Cumulative Effect Adjustment
Total
Balance (in shares) at Dec. 31, 2019 61,935,870              
Balance at the beginning of the period at Dec. 31, 2019 $ 62   $ 1,795,351 $ (10,584)   $ (1,190,499)   $ 594,330
Increase (Decrease) in Stockholders' Equity                
Issuance of common stock related to equity offerings (in shares) 368,514              
Issuance of common stock related to equity offering     18,950         18,950
Issuance of common stock related to acquisition (in shares) 845,364              
Issuance of common stock related to acquisition $ 1   42,868         42,869
Issuance of common stock related to rights exchange (in shares) 2,821,176              
Issuance of common stock related to rights exchange $ 3   150,525         150,528
Exercise of options (in shares) 1,034,288              
Exercise of options $ 1   25,044         25,045
Restricted stock vesting and issuance (in shares) 176,776              
Issuance of common stock in connection with an employee stock purchase plan (in shares) 58,691              
Issuance of common stock in connection with an employee stock purchase plan     2,406         2,406
Share-based compensation expense     32,130         32,130
Other           (218)   (218)
Net loss           (294,114)   (294,114)
Comprehensive income (loss)       568       568
Balance (in shares) at Jun. 30, 2020 67,240,679              
Balance at the end of the period at Jun. 30, 2020 $ 67   2,067,274 (10,016)   (1,484,831)   572,494
Balance (in shares) at Mar. 31, 2020 62,758,520              
Balance at the beginning of the period at Mar. 31, 2020 $ 62   1,834,061 (1,985)   (1,303,404)   528,734
Increase (Decrease) in Stockholders' Equity                
Issuance of common stock related to equity offerings (in shares) 106,309              
Issuance of common stock related to equity offering     5,447         5,447
Issuance of common stock related to acquisition (in shares) 845,364              
Issuance of common stock related to acquisition $ 1   42,868         42,869
Issuance of common stock related to rights exchange (in shares) 2,821,176              
Issuance of common stock related to rights exchange $ 3   150,525         150,528
Exercise of options (in shares) 654,604              
Exercise of options $ 1   15,057         15,058
Restricted stock vesting and issuance (in shares) (3,985)              
Issuance of common stock in connection with an employee stock purchase plan (in shares) 58,691              
Issuance of common stock in connection with an employee stock purchase plan     2,406         2,406
Share-based compensation expense     16,910         16,910
Net loss           (181,427)   (181,427)
Comprehensive income (loss)       (8,031)       (8,031)
Balance (in shares) at Jun. 30, 2020 67,240,679              
Balance at the end of the period at Jun. 30, 2020 $ 67   2,067,274 (10,016)   (1,484,831)   572,494
Balance (in shares) at Dec. 31, 2020 69,718,096              
Balance at the beginning of the period at Dec. 31, 2020 $ 70 $ (175,236) 2,171,746 (60,957) $ 54,796 (1,628,877) $ (120,440) 481,982
Increase (Decrease) in Stockholders' Equity                
Exercise of options (in shares) 475,942              
Exercise of options     13,144         13,144
Restricted stock vesting and issuance (in shares) 292,171              
Issuance of common stock in connection with an employee stock purchase plan (in shares) 73,121              
Issuance of common stock in connection with an employee stock purchase plan     2,627         2,627
Share-based compensation expense     51,406         51,406
Net loss           (247,012)   (247,012)
Comprehensive income (loss)       14,870       14,870
Balance (in shares) at Jun. 30, 2021 70,559,330              
Balance at the end of the period at Jun. 30, 2021 $ 70   2,063,687 (46,087)   (1,821,093)   196,577
Balance (in shares) at Mar. 31, 2021 70,405,905              
Balance at the beginning of the period at Mar. 31, 2021 $ 70   2,033,972 (38,743)   (1,702,723)   292,576
Increase (Decrease) in Stockholders' Equity                
Exercise of options (in shares) 60,159              
Exercise of options     1,389         1,389
Restricted stock vesting and issuance (in shares) 20,145              
Issuance of common stock in connection with an employee stock purchase plan (in shares) 73,121              
Issuance of common stock in connection with an employee stock purchase plan     2,627         2,627
Share-based compensation expense     25,699         25,699
Net loss           (118,370)   (118,370)
Comprehensive income (loss)       (7,344)       (7,344)
Balance (in shares) at Jun. 30, 2021 70,559,330              
Balance at the end of the period at Jun. 30, 2021 $ 70   $ 2,063,687 $ (46,087)   $ (1,821,093)   $ 196,577