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v3.21.2

Consolidated Statements of Operations - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020
Revenues: |  |  |  |
Revenue | $ 138,743 | $ 118,404 | $ 373,364 | $ 261,902
Operating expenses: |  |  |  |
Cost of product sales, excluding amortization of acquired intangible assets | 6,539 | 4,667 | 23,001 | 14,056
Amortization of acquired intangible assets | 14,383 | 9,630 | 38,411 | 26,309
Research and development | 130,845 | 92,998 | 390,840 | 359,630
Selling, general and administrative | 69,252 | 57,840 | 199,225 | 169,708
Change in the fair value of deferred and contingent consideration | 10,800 | 8,400 | 11,600 | 16,980
Settlement of deferred and contingent consideration |  |  |  | 10,613
Total operating expenses | 231,819 | 173,535 | 663,077 | 597,296
Loss from operations | (93,076) | (55,131) | (289,713) | (335,394)
Interest expense, net | (21,802) | (21,039) | (63,520) | (32,060)
Other (expense) income, net | (18,782) | 28,766 | (26,499) | 26,242
Loss before income tax expense | (133,660) | (47,404) | (379,732) | (341,212)
Income tax benefit (expense) | 36 | (22,288) | (904) | (22,594)
Net loss attributable to common stockholders | $ (133,624) | $ (69,692) | $ (380,636) | $ (363,806)
Weighted-average shares outstanding: |  |  |  |
Basic and diluted (in shares) | 70,585,938 | 67,641,171 | 70,397,846 | 65,068,281
Net loss per share-basic and diluted (in dollars per share) |  |  |  |
Net loss per share-basic and diluted (in dollars per share) | $ (1.89) | $ (1.03) | $ (5.41) | $ (5.59)
Net product revenue |  |  |  |
Revenues: |  |  |  |
Revenue | $ 115,605 | $ 82,708 | $ 309,998 | $ 226,143
Collaboration revenue |  |  |  |
Revenues: |  |  |  |
Revenue | 10,011 | 35,000 | 30,018 | 35,063
Royalty revenue |  |  |  |
Revenues: |  |  |  |
Revenue | $ 13,127 | $ 696 | $ 33,348 | $ 696

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- Definition The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.4) -URI http://asc.fasb.org/extlink&oid=120395209&loc=SL114868664-224227 + Details
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