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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) $ in Thousands | Sep. 30, 2021 USD ($) | Dec. 31, 2020 USD ($) | Sep. 30, 2020 USD ($) | Dec. 31, 2019 USD ($)
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Level 3 | Contingent Consideration Payable |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Fair value | $ 140,200 | $ 139,200 | $ 138,200 | $ 290,500
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | 0 | 0 |  |
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | $ 381,000 | $ 381,000 |  |
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.25 | 0.25 |  |
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.94 | 0.94 |  |
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.016 | 0.022 |  |
Agilis | Development and Regulatory Milestone | Contingent Consideration Payable | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.047 | 0.045 |  |
Agilis | Development and Regulatory Milestone | Level 3 | Contingent Consideration Payable |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Fair value | $ 140,200 | $ 139,200 |  |
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | 0 | 0 |  |
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | $ 150,000 | $ 150,000 |  |
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Probability of Success | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.25 | 0.25 |  |
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Probability of Success | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.94 | 0.94 |  |
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.02 | 0.02 |  |
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.06 | 0.06 |  |
Agilis | Net Sales Milestones and Royalties | Contingent Consideration Payable | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.110 | 0.115 |  |
Agilis | Net Sales Milestones and Royalties | Level 3 |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Fair value | $ 111,800 | $ 101,200 | $ 95,900 | $ 65,800
Agilis | Net Sales Milestones and Royalties | Level 3 | Contingent Consideration Payable |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Fair value | $ 111,800 | $ 101,200 |  |

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