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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 37 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Apr. 20, 2017 | Aug. 31, 2021 | Dec. 31, 2019 | May 31, 2019 | Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Dec. 31, 2019 | Sep. 30, 2021 | Dec. 31, 2020 | Aug. 23, 2018
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Amortization of acquired intangible assets |  |  |  |  | $ 14,383 | $ 9,630 | $ 38,411 | $ 26,309 |  |  |  |
Total allocation of IPR&D assets |  |  |  |  |  |  | 576,500 |  |  |  |  |
Change in indefinite-lived intangibles |  |  |  |  |  |  |  |  |  | $ 0 |  |
Goodwill |  |  |  |  | 82,341 |  | 82,341 |  |  | 82,341 | $ 82,341 | $ 82,300
Changes in goodwill |  |  |  |  | 0 |  | $ 0 |  |  |  |  |
Weighted Average |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Remaining amortization period |  |  |  |  |  |  | 2 years 10 months 24 days |  |  |  |  |
Akcea |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  | $ 4,000 |  |  |  |  |  |  |  |  |  |
Agilis Merger Agreement | Akcea |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  |  | $ 4,000 | $ 6,000 |  |  | $ 4,000 |  | $ 6,000 |  |  |
Useful life |  |  | 10 years |  |  |  |  |  |  |  |  |
Emflaza asset acquisition |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangibles | $ 148,400 |  |  |  |  |  |  |  |  |  |  |
Milestone obligation payments recorded |  |  |  |  | 16,800 | $ 13,000 | 42,800 | $ 28,000 |  |  |  |
Useful life | 7 years |  |  |  |  |  |  |  |  |  |  |
Emflaza asset acquisition | Accounts payable and accrued expenses |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payable |  |  |  |  | $ 19,200 |  | $ 19,200 |  |  | $ 19,200 |  |

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