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Fair value of financial instruments and marketable securities - Fair Value Measurement Inputs and Valuation Techniques (Details) - Level 3 $ in Thousands | 9 Months Ended
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Sep. 30, 2021 USD ($) | Sep. 30, 2020 USD ($)
Contingent Consideration Payable |  |
Level 3 roll forward |  |
Beginning Balance | $ 139,200 | $ 290,500
Additions | 0 | 0
Change in fair value | 1,000 | (13,120)
Payments | 0 | $ 0
Rights Exchange settlement |  | (139,180)
Ending Balance | 140,200 | $ 138,200
Net Sales Milestones and Royalties | Agilis |  |
Level 3 roll forward |  |
Beginning Balance | 101,200 | 65,800
Additions | 0 | 0
Change in fair value | 10,600 | 30,100
Payments | 0 | $ 0
Rights Exchange settlement |  | 0
Ending Balance | 111,800 | $ 95,900
Net Sales Milestones and Royalties | Agilis | Contingent Consideration Payable |  |
Level 3 roll forward |  |
Beginning Balance | 101,200 |
Ending Balance | $ 111,800 |

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- Definition Value of input used to measure alternative investment. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb)(2) -URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258 + Details
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- Definition Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258 + Details
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- Definition Amount of issuances of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258 + Details
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- Definition Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258 + Details
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