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Stock award plan - (Tables)

9 Months Ended

Sep. 30, 2021

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​		​		​	​		Weighted-			​	​
​	​	​	​	Weighted-		​	average	​	​	Aggregate
​	​	​	​	average		​	remaining	​	​	intrinsic
​	​	Number of	​	exercise		​	contractual	​	​	value(in
​	​	options	​	price		​	term	​	​	thousands)
​	​	​	​	​	​	​	​		​	​	​
Outstanding at December 31, 2020		9,663,677	​	$	38.72				​	​
Granted		2,403,484	​	​	62.21				​	​
Exercised		(574,230)	​	​	28.11				​	​
Forfeited/Cancelled		(610,850)	​	​	52.52				​	​
Outstanding at September 30, 2021		10,882,081	​	$	43.70		7.16	years	​	$	39,772
Vested or Expected to vest at September 30, 2021		4,802,564	​	$	50.12		8.47	years	​	$	6,311
Exercisable at September 30, 2021		5,585,904	​	$	37.32		5.88	years	​	$	33,232

​

Schedule of assumptions used to estimate fair values of grants made on the date of grant

​

​	​	​
​		Nine months ended
​		September 30, 2021
Risk-free interest rate		0.51%-1.05%
Expected volatility		77.53%-88.61%
Expected term		5.5 years

Summary of information on the Company's restricted stock

​

​	​	​	​	​	​
​	​	Restricted Stock Awards and Units
​	​	​	​	Weighted
​	​	​	​	Average
​	​	​	​	Grant
​	​	Number of	​	Date
​		Shares		Fair Value
Unvested at December 31, 2020	​	982,058	​	$	41.78
Granted		994,603	​	​	63.15
Vested		(326,519)	​	​	35.49
Forfeited		(113,877)	​	​	57.95
Unvested at September 30, 2021		1,536,265	​	$	55.76

Schedule of share-based compensation expense recorded in the statement of operations

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Three Months Ended September 30,

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Nine Months Ended September 30,

​

​

2021

2020

2021

2020

​

Research and development

​

$

13,048

​

$

9,220

​

$

40,216

​

$

25,961

​

Selling, general and administrative

​

12,823

​

7,559

​

37,061

​

22,948

​

Total

​

$

25,871

​

$

16,779

​

$

77,277

​

$

48,909

​

​

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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