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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Revenues:        
Revenue $ 138,743 $ 118,404 $ 373,364 $ 261,902
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible assets 6,539 4,667 23,001 14,056
Amortization of acquired intangible assets 14,383 9,630 38,411 26,309
Research and development 130,845 92,998 390,840 359,630
Selling, general and administrative 69,252 57,840 199,225 169,708
Change in the fair value of deferred and contingent consideration 10,800 8,400 11,600 16,980
Settlement of deferred and contingent consideration       10,613
Total operating expenses 231,819 173,535 663,077 597,296
Loss from operations (93,076) (55,131) (289,713) (335,394)
Interest expense, net (21,802) (21,039) (63,520) (32,060)
Other (expense) income, net (18,782) 28,766 (26,499) 26,242
Loss before income tax expense (133,660) (47,404) (379,732) (341,212)
Income tax benefit (expense) 36 (22,288) (904) (22,594)
Net loss attributable to common stockholders $ (133,624) $ (69,692) $ (380,636) $ (363,806)
Weighted-average shares outstanding:        
Basic and diluted (in shares) 70,585,938 67,641,171 70,397,846 65,068,281
Net loss per share-basic and diluted (in dollars per share)        
Net loss per share-basic and diluted (in dollars per share) $ (1.89) $ (1.03) $ (5.41) $ (5.59)
Net product revenue        
Revenues:        
Revenue $ 115,605 $ 82,708 $ 309,998 $ 226,143
Collaboration revenue        
Revenues:        
Revenue 10,011 35,000 30,018 35,063
Royalty revenue        
Revenues:        
Revenue $ 13,127 $ 696 $ 33,348 $ 696