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Debt - (Tables)

9 Months Ended

Sep. 30, 2021

Debt Instrument, Redemption [Line Items]

Summary of liability for sale of future royalties


		Nine Months Ended September 30,
Liability for sale of future royalties- (current and noncurrent)		2021
Beginning balance as of December 31, 2020		$	679,762
Less: Non-cash royalty revenue payable to RPI			(14,317)
Plus: Non-cash interest expense recognized			57,755
Ending balance		$	723,200
Effective interest rate as of September 30, 2021			11	%

1.50% Convertible senior notes due 2026

Debt Instrument, Redemption [Line Items]

Summary of convertible notes


Liability component		September 30, 2021			December 31, 2020
Principal		$	287,500		$	287,500
Less: Debt issuance costs			(5,896)			(4,058)
Less: Debt discount, net(1)			—			(106,065)
Net carrying amount		$	281,604		$	177,377

Summary of interest expense recognized related to the Convertible Notes



		Three Months Ended September 30,							Nine Months Ended September 30,
		2021				2020			2021				2020
Contractual interest expense		$	1,081		$	1,081			$	3,217		$	3,223
Amortization of debt issuance costs			283			127				839			374
Amortization of debt discount			—			3,313				—			9,786
Total		$	1,364		$	4,521			$	4,056		$	13,383
Effective interest rate of the liability component			1.9	%		10.2	%			1.9	%		10.2	%

3.00% Convertible senior notes due 2022

Debt Instrument, Redemption [Line Items]

Summary of convertible notes




Liability component		September 30, 2021			December 31, 2020
Principal		$	150,000		$	150,000
Less: Debt issuance costs			(642)			(865)
Less: Debt discount, net (1)			—			(17,372)
Net carrying amount		$	149,358		$	131,763

Summary of interest expense recognized related to the Convertible Notes



		Three Months Ended September 30,						Nine Months Ended September 30,
		2021			2020			2021			2020
Contractual interest expense		$	1,134		$	1,131		$	3,375		$	3,375
Amortization of debt issuance costs			182			118			538			343
Amortization of debt discount			—			2,372			—			6,892
Total		$	1,316		$	3,621		$	3,913		$	10,610
Effective interest rate of the liability component			3.5	%		11.0	%		3.5	%		11.0	%