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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Collaboration and royalty revenue
Revenue	$ 138,743	$ 118,404	$ 373,364	$ 261,902
Collaboration revenue
Collaboration and royalty revenue
Revenue	10,011	35,000	30,018	35,063
Royalty revenue
Collaboration and royalty revenue
Revenue	13,127	696	33,348	696
SMA License Agreement | Collaboration revenue
Collaboration and royalty revenue
Revenue	10,000	35,000	30,000	35,100
SMA License Agreement | Royalty revenue
Collaboration and royalty revenue
Revenue	$ 13,100	$ 700	$ 33,300	$ 700

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