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Fair value of financial instruments and marketable securities - Fair Value Measurement Inputs and Valuation Techniques (Details) - Level 3 $ in Thousands	9 Months Ended
	Sep. 30, 2021 USD ($)	Sep. 30, 2020 USD ($)
Contingent Consideration Payable
Level 3 roll forward
Beginning Balance	$ 139,200	$ 290,500
Additions	0	0
Change in fair value	1,000	(13,120)
Payments	0	$ 0
Rights Exchange settlement		(139,180)
Ending Balance	140,200	$ 138,200
Net Sales Milestones and Royalties | Agilis
Level 3 roll forward
Beginning Balance	101,200	65,800
Additions	0	0
Change in fair value	10,600	30,100
Payments	0	$ 0
Rights Exchange settlement		0
Ending Balance	111,800	$ 95,900
Net Sales Milestones and Royalties | Agilis | Contingent Consideration Payable
Level 3 roll forward
Beginning Balance	101,200
Ending Balance	$ 111,800

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- Definition

Value of input used to measure alternative investment.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (bbb)(2)
-URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258

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Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3).

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
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-URI http://asc.fasb.org/extlink&oid=117815213&loc=d3e19207-110258

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Amount of issuances of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

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-Topic 820
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-Section 50
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- Definition

Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

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- Definition

Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

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-Topic 820
-SubTopic 10
-Section 50
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