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Stock award plan - Share Base Compensation (Details) - Stock option - USD ($)
$ / shares in Units, $ in Thousands
9 Months Ended
Sep. 30, 2021
Number of options  
Outstanding at the beginning of the period (in shares) 9,663,677
Granted (in shares) 2,403,484
Exercised (in shares) (574,230)
Forfeited/Cancelled (in shares) (610,850)
Outstanding at the end of the period (in shares) 10,882,081
Vested or Expected to vest at the end of the period (in shares) 4,802,564
Exercisable at the end of the period (in shares) 5,585,904
Weighted- average exercise price  
Outstanding at the beginning of the period (in dollars per share) $ 38.72
Granted (in dollars per share) 62.21
Exercised (in dollars per share) 28.11
Forfeited/Cancelled (in dollars per share) 52.52
Outstanding at the end of the period (in dollars per share) 43.70
Vested or Expected to vest at the end of the period (in dollars per share) 50.12
Exercisable at the end of the period (in dollars per share) $ 37.32
Weighted- average remaining contractual term  
Outstanding at the end of the period 7 years 1 month 28 days
Vested or Expected to vest at the end of the period 8 years 5 months 19 days
Exercisable at the end of the period 5 years 10 months 17 days
Aggregate intrinsic value (in thousands)  
Outstanding at the end of the period (in dollars) $ 39,772
Vested or Expected to vest at the end of the period (in dollars) 6,311
Exercisable at the end of the period (in dollars) $ 33,232
Valuation assumptions  
Expected term (in years) 5 years 6 months
Minimum  
Valuation assumptions  
Risk-free interest rate (as a percent) 0.51%
Expected volatility (as a percent) 77.53%
Maximum  
Valuation assumptions  
Risk-free interest rate (as a percent) 1.05%
Expected volatility (as a percent) 88.61%