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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Common stock
Additional paid-in capital
Cumulative Effect Adjustment
Additional paid-in capital
Accumulated other comprehensive income (loss)
Accumulated deficit
Cumulative Effect Adjustment
Accumulated deficit
Cumulative Effect Adjustment
Total
Balance (in shares) at Dec. 31, 2019 61,935,870              
Balance at the beginning of the period at Dec. 31, 2019 $ 62   $ 1,795,351 $ (10,584)   $ (1,190,499)   $ 594,330
Increase (Decrease) in Stockholders' Equity                
Issuance of common stock related to equity offerings (in shares) 542,470              
Issuance of common stock related to equity offering $ 1   28,091         28,092
Issuance of common stock related to acquisition (in shares) 845,364              
Issuance of common stock related to acquisition $ 1   42,868         42,869
Issuance of common stock related to rights exchange (in shares) 2,821,176              
Issuance of common stock related to rights exchange $ 3   150,525         150,528
Exercise of options (in shares) 1,426,026              
Exercise of options $ 1   32,986         32,987
Restricted stock vesting and issuance (in shares) 179,963              
Issuance of common stock in connection with an employee stock purchase plan (in shares) 58,691              
Issuance of common stock in connection with an employee stock purchase plan     2,406         2,406
Share-based compensation expense     48,909         48,909
Other           (218)   (218)
Net loss           (363,806)   (363,806)
Comprehensive income (loss)       (25,143)       (25,143)
Balance (in shares) at Sep. 30, 2020 67,809,560              
Balance at the end of the period at Sep. 30, 2020 $ 68   2,101,136 (35,727)   (1,554,523)   510,954
Balance (in shares) at Jun. 30, 2020 67,240,679              
Balance at the beginning of the period at Jun. 30, 2020 $ 67   2,067,274 (10,016)   (1,484,831)   572,494
Increase (Decrease) in Stockholders' Equity                
Issuance of common stock related to equity offerings (in shares) 173,956              
Issuance of common stock related to equity offering     9,141         9,141
Exercise of options (in shares) 391,738              
Exercise of options $ 1   7,942         7,943
Restricted stock vesting and issuance (in shares) 3,187              
Share-based compensation expense     16,779         16,779
Net loss           (69,692)   (69,692)
Comprehensive income (loss)       (25,711)       (25,711)
Balance (in shares) at Sep. 30, 2020 67,809,560              
Balance at the end of the period at Sep. 30, 2020 $ 68   2,101,136 (35,727)   (1,554,523)   510,954
Balance (in shares) at Dec. 31, 2020 69,718,096              
Balance at the beginning of the period at Dec. 31, 2020 $ 70 $ (175,236) 2,171,746 (60,957) $ 54,796 (1,628,877) $ (120,440) 481,982
Increase (Decrease) in Stockholders' Equity                
Exercise of options (in shares) 574,230              
Exercise of options     16,120         16,120
Restricted stock vesting and issuance (in shares) 299,563              
Issuance of common stock in connection with an employee stock purchase plan (in shares) 73,121              
Issuance of common stock in connection with an employee stock purchase plan     2,627         2,627
Share-based compensation expense     77,277         77,277
Net loss           (380,636)   (380,636)
Comprehensive income (loss)       27,996       27,996
Balance (in shares) at Sep. 30, 2021 70,665,010              
Balance at the end of the period at Sep. 30, 2021 $ 70   2,092,534 (32,961)   (1,954,717)   104,926
Balance (in shares) at Jun. 30, 2021 70,559,330              
Balance at the beginning of the period at Jun. 30, 2021 $ 70   2,063,687 (46,087)   (1,821,093)   196,577
Increase (Decrease) in Stockholders' Equity                
Exercise of options (in shares) 98,288              
Exercise of options     2,976         2,976
Restricted stock vesting and issuance (in shares) 7,392              
Share-based compensation expense     25,871         25,871
Net loss           (133,624)   (133,624)
Comprehensive income (loss)       13,126       13,126
Balance (in shares) at Sep. 30, 2021 70,665,010              
Balance at the end of the period at Sep. 30, 2021 $ 70   $ 2,092,534 $ (32,961)   $ (1,954,717)   $ 104,926