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Stock award plan - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended			3 Months Ended		9 Months Ended
	Dec. 31, 2020	Jun. 30, 2016	May 31, 2013	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020	Jun. 30, 2021	May 31, 2021	Jan. 31, 2020
Stock option plan
Share-based compensation expense				$ 25,871	$ 16,779	$ 77,277	$ 48,909
Restricted stock
Stock option plan
Grants in period (in shares)						994,603
Stock option
Stock option plan
Granted (in shares)						2,403,484
Expected dividend yield (as a percent)						0.00%
Weighted average grant date fair value (in dollars per share)						$ 43.75
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock
Stock option plan
Number of shares available for issuance				0		0
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock | Maximum
Stock option plan
Number of shares subject to outstanding awards (in shares)			3,040,444
2009 Equity and Long Term Incentive Plan and 2013 Stock Incentive Plan | Common stock
Stock option plan
Number of shares available for issuance			122,296
2013 Long Term Incentive Plan | Minimum
Stock option plan
Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase Number			2,500,000
Annual increase in the number of shares outstanding on the first day of the fiscal year			4.00%
2013 Long Term Incentive Plan | Common stock
Stock option plan
Number of shares available for issuance				930,840		930,840
2020 Inducement Stock Incentive Plan | Common stock
Stock option plan
Number of shares available for issuance				857,693		857,693
Number of additional shares authorized (in shares)	1,000,000
2020 Inducement Stock Incentive Plan | Common stock | Maximum
Stock option plan
Number of shares authorized (in shares)										1,000,000
2020 Inducement Stock Incentive Plan | Stock option
Stock option plan
Inducement grants for non-statutory stock options (in shares)						309,095
2020 Inducement Stock Incentive Plan | Restricted stock units
Stock option plan
Grants in period (in shares)						107,085
Employee Stock Purchase Plan
Stock option plan
Number of shares authorized (in shares)								2,000,000	1,000,000
Share-based compensation expense				$ 500		$ 1,800
Award requisite service period		6 months
Purchase price of common stock, percent		85.00%
Employee stock purchase plan, voting percentage limit		5.00%

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Employee Stock Purchase Plan, Voting Percentage Limit, Percent

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Represents the percentage of shares outstanding to be added annually on the first day of each fiscal year in the number of shares authorized.

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Represents the number of shares to be added annually on the first day of each fiscal year in the number of shares authorized.

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Represents the number of shares subject to outstanding awards used to calculate authorized shares.

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Represents the inducement grants for non-statutory stock options.

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Estimated period over which an employee is required to provide service in exchange for the equity-based payment award, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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Number of additional shares authorized for issuance under share-based payment arrangement.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Gross number of share options (or share units) granted during the period.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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