<SEC-DOCUMENT>0001104659-21-030815.txt : 20210302
<SEC-HEADER>0001104659-21-030815.hdr.sgml : 20210302
<ACCEPTANCE-DATETIME>20210302164520
ACCESSION NUMBER:		0001104659-21-030815
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20210302
DATE AS OF CHANGE:		20210302

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ClearPoint Neuro, Inc.
		CENTRAL INDEX KEY:			0001285550
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				582394628
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-86852
		FILM NUMBER:		21704511

	BUSINESS ADDRESS:	
		STREET 1:		5 MUSICK
		CITY:			IRVINE
		STATE:			CA
		ZIP:			92618
		BUSINESS PHONE:		9499006833

	MAIL ADDRESS:	
		STREET 1:		5 MUSICK
		CITY:			IRVINE
		STATE:			CA
		ZIP:			92618

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MRI INTERVENTIONS, INC.
		DATE OF NAME CHANGE:	20110714

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SURGIVISION INC
		DATE OF NAME CHANGE:	20091106

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SURGI VISION INC
		DATE OF NAME CHANGE:	20040331

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PTC THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001070081
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043416587
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		100 CORPORATE COURT
		CITY:			SOUTH PLAINFIELD
		STATE:			NJ
		ZIP:			07080-2449
		BUSINESS PHONE:		9082227000

	MAIL ADDRESS:	
		STREET 1:		100 CORPORATE COURT
		CITY:			SOUTH PLAINFIELD
		STATE:			NJ
		ZIP:			07080-2449

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PTC THERAPEUTICS INC
		DATE OF NAME CHANGE:	19980909
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>tm218429d1_sc13da.htm
<DESCRIPTION>SCHEDULE 13D/A
<TEXT>
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<!-- Field: Rule-Page --><DIV STYLE="margin-top: 12pt; margin-bottom: 3pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top; width: 23%; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 55%; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt"><B>UNITED STATES</B></TD>
    <TD STYLE="vertical-align: bottom; width: 22%; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt">&nbsp;</TD>
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt"><B>SECURITIES AND EXCHANGE COMMISSION</B></TD>
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt"><FONT STYLE="font-size: 10pt"><B>Washington, D.C. 20549</B></FONT></TD>
    <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 10pt; text-align: center; text-indent: -10pt"><B>SCHEDULE 13D</B></TD>
    <TD STYLE="vertical-align: bottom; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Under the Securities Exchange Act of
1934<BR>
(Amendment No. 2)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 1pt solid"><B>ClearPoint
Neuro, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 1pt solid"><B>Common
Stock, par value $0.01 per share</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 1pt solid"><B>55347P209</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Mark E. Boulding</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Executive Vice President and Chief Legal
Officer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PTC Therapeutics, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>100 Corporate Court</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>South Plainfield, NJ 07080 </B></P>

<P STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(908) 222-7000</B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, Address and Telephone Number of Person<BR>
Authorized to Receive Notices and Communications)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: black 1pt solid"><B>February
23, 2021</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Date of Event Which Requires Filing of
this Statement)<BR>
<BR>
</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">If the filing person has previously filed a statement on
Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of &sect;&sect;240.13d-1(e),
240.13d-1(f) or 240.13d-1(g), check the following box. <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">* The remainder of this cover page shall be filled out for
a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent
amendment containing information which would alter disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in">The information required on the remainder of this cover
page shall not be deemed to be &#8220;filed&#8221; for the purpose of section 18 of the Securities Exchange Act of 1934, as amended
(&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 100%; border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">CUSIP No.&nbsp; &nbsp;55347P209</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">1.</FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Names of Reporting Persons<BR>
PTC Therapeutics, Inc.</FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Check the Appropriate Box if a Member of a Group</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 4pt 3pt 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 4pt 3pt 3pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 4pt 3pt 3pt"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 4pt 3pt 3pt"><FONT STYLE="font-size: 10pt">&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR>
    <TD STYLE="padding: 4pt 3pt 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 4pt 3pt 3pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 4pt 3pt 3pt"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 4pt 3pt 3pt"><FONT STYLE="font-size: 10pt">&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">SEC Use Only </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Source of Funds (See Instructions)<BR>
WC</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">5.</FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)&nbsp; &nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Citizenship or Place of Organization<BR>
Delaware</FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="3" ROWSPAN="7" STYLE="padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Number of<BR>
Shares<BR>
Beneficially<BR>
Owned by<BR>
Each<BR>
Reporting<BR>
Person<BR>
 With:</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Sole Voting Power <BR>
2,961,245 (1)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Shared Voting Power <BR>
0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Sole Dispositive Power <BR>
2,961,245 (1)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Shared Dispositive Power <BR>
0</FONT></TD></TR>
<TR>
    <TD COLSPAN="6"><FONT STYLE="font-size: 0pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 84%">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 3%; padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
    <TD STYLE="width: 92%; border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Aggregate Amount Beneficially Owned by Each Reporting Person <BR>
2,961,245 (1)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)&nbsp;&nbsp; <FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">13.</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Percent of Class Represented by Amount in Row (11) <BR>
14.00% (1)(2)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 4pt; padding-bottom: 4pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">14.</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; padding-top: 4pt; padding-bottom: 4pt"><FONT STYLE="font-size: 10pt">Type of Reporting Person (See Instructions)</FONT><BR>
<FONT STYLE="font-size: 10pt">CO</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD STYLE="width: 97%"><FONT STYLE="font-size: 10pt">This number represents the sum of (i) 1,294,578 &nbsp;shares of the
    Issuer&#8217;s common stock (&#8220;Common Stock&#8221;) currently held by the reporting person (&#8220;PTC&#8221;),
    including the 4,255 shares of Common Stock acquired by the reporting person on February 23, 2021 in the Public Offering
    (defined below) and 1,290,323 shares of Common Stock previously acquired by the reporting person as previously reported on
    May 24, 2019, and (ii) 1,666,667 shares of Common Stock, which represents the maximum number of shares of Common Stock that
    could be issued to PTC in connection with the conversion of a senior secured convertible note having a principal amount of
    $10,000,000 (the &#8220;PTC Note&#8221;), which PTC Note was previously acquired by the reporting person as previously
    reported on January 31, 2020, subject to adjustment as provided in the PTC Note.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">(2)</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Based on 21,153,289 shares of the Common Stock calculated based on (i) 17,358,962 shares of the Common Stock outstanding as of February 1, 2021, as set forth in the Issuer&#8217;s prospectus supplement filed with the United States Securities and Exchange Commission (the &#8220;SEC&#8221;) on February 19, 2021, plus 2,127,660 shares of Common Stock issued in the Issuer&#8217;s underwritten public offering of Common Stock, which closed on February 23, 2021 (the &#8220;Public Offering&#8221;) including the exercise in full by the underwriters of their option to purchase an additional 277,520 of the Common Stock, and (ii) 1,666,667 shares of Common Stock, which represents the maximum number of shares of Common Stock that could be issued to PTC in connection with the conversion of the PTC Note, subject to adjustment as provided in the PTC Note.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in"><B>Item 1.&nbsp;&nbsp; Security
and Issuer.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This Amendment No.&nbsp;2 amends the statement
on Schedule 13D originally filed with the SEC on May&nbsp;24, 2019, as amended by Amendment No. 1 to Schedule 13D filed with the
SEC on January 31, 2020 (together, this &#8220;Schedule 13D&#8221;). This Schedule 13D relates to the common stock, par value $0.01
per share (the &#8220;Common Stock&#8221;), of ClearPoint Neuro,&nbsp;Inc., a Delaware corporation (the &#8220;Issuer&#8221;).
The address of the Issuer&#8217;s principal executive office is 5 Musick,&nbsp;Irvine, California 92618.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The reporting person is filing this Amendment
No. 2 to the Schedule 13D to report the decrease in the percentage of the class beneficially owned by the reporting person due
to an increase in the aggregate number of outstanding securities of the Issuer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The information set forth in response to
each separate Item below shall be deemed to be a response to all Items where such information is relevant. The Schedule 13D is
supplementally amended as follows. Except as expressly stated herein, there have been no material changes in the information set
forth in the Schedule 13D.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in"><B>Item 3.&nbsp;&nbsp; Source
and Amounts of Funds or Other Consideration.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 3 of the Schedule 13D is hereby amended as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">On February 23, 2021, PTC acquired 4,255
shares of Common Stock pursuant to the Public Offering for an aggregate purchase price of $99,992.50.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The source of funds for the purchase of
the Common Stock acquired in the Public Offering was working capital of PTC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in"><B>Item 5.&nbsp;&nbsp; Interest
in Securities of the Issuer.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Item 5 of the Schedule 13D is hereby amended as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
As of the date of this Schedule 13D, PTC beneficially owned 2,961,245 shares of Common Stock, including 4,255 shares of
Common Stock acquired in the Issuer&#8217;s Public Offering, 1,290,323 shares of Common Stock previously acquired by the
reporting person  as previously reported on May 24, 2019, and 1,666,667 shares of Common Stock representing the maximum
number of shares of Common Stock that could be issued to PTC in connection with the conversion of the PTC Note, which PTC
Note was previously acquired by the reporting person as previously reported on January 31, 2020, subject to adjustment as
provided in the PTC Note. Based on 21,153,289 outstanding shares of the Common Stock, calculated based on (i) 17,358,962
shares of the Common Stock outstanding as of February 1, 2021, as set forth in the Issuer&#8217;s prospectus supplement filed
with the United States Securities and Exchange Commission on February 19, 2021, plus 2,127,660 shares of the Common Stock
issued in the Public Offering including the exercise in full by the underwriters of their option to purchase an additional
277,520 of the Common Stock, and (ii) 1,666,667 shares of the Common Stock, which represents the maximum number of shares of
Common Stock that could be issued to PTC in connection with the conversion of the PTC Note, subject to adjustment as provided
in the PTC Note, the shares of Common Stock beneficially owned by PTC constitute 14.00% of the outstanding shares of Common
Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
PTC has sole voting power and dispositive power with respect to all shares of Common Stock that it beneficially owns.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
The information contained in Item 3 above is incorporated herein by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Signature</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.3pt; text-indent: 35.7pt">After reasonable inquiry and
to the best of the undersigned&#8217;s knowledge and belief, the undersigned hereby certifies that the information set forth in
this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0.5in"><FONT STYLE="font-size: 10pt">Date: March 2, 2021</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">PTC Therapeutics,&nbsp;Inc.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; padding-left: 0.5in">&nbsp;</TD>
    <TD STYLE="width: 4.5%">&nbsp;</TD>
    <TD STYLE="width: 45.5%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Mark E. Boulding</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Mark E. Boulding</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title:</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Executive Vice President and Chief Legal Officer</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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