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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
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Payables and Accruals [Abstract] |  |
Employee compensation, benefits, and related accruals | $ 55,733 | $ 53,291
Income tax payable | 1,287 | 4,315
Consulting and contracted research | 26,434 | 18,250
Professional fees | 3,547 | 3,614
Sales allowance | 61,662 | 54,327
Sales rebates | 68,770 | 63,774
Royalties | 35,679 | 16,575
Accounts payable | 23,033 | 18,665
Other | 12,639 | 9,357
Accounts payable and accrued expenses | $ 288,784 | $ 242,168

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