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Fair value of financial instruments and investments - Convertible Notes and Rights Exchange Agreement (Details) - USD ($) |  | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Apr. 29, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Sep. 30, 2019 | Aug. 31, 2015
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Deferred consideration payable |  |  | $ 0 |  |  |
Payments on deferred consideration obligation |  |  | 38,100,000 |  |  |
Issuance of common stock related to rights exchange |  |  | 150,528,000 |  |  |
Contingent consideration payable |  | $ 239,900,000 | 240,400,000 |  |  |
3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Principal |  | 150,000,000 | 150,000,000 |  |  | $ 150,000,000.0
Interest rate ( as a percent ) |  |  |  |  |  | 3.00%
1.50% Convertible senior notes due 2026 | Convertible debt |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Principal |  | 287,500,000 | 287,500,000 |  | $ 287,500,000 |
Interest rate ( as a percent ) |  |  |  |  | 1.50% |
Significant other observable inputs (Level 2) | 3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Fair value of convertible notes |  | 158,300,000 | 193,200,000 |  |  |
Significant other observable inputs (Level 2) | 1.50% Convertible senior notes due 2026 | Convertible debt |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Fair value of convertible notes |  | 305,300,000 | 394,900,000 |  |  |
Development and Regulatory Milestones | Recurring basis |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Contingent consideration payable |  | 139,300,000 | 139,200,000 |  |  |
Development and Regulatory Milestones | Recurring basis | Significant unobservable inputs (Level 3) |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Contingent consideration payable |  | 139,300,000 | 139,200,000 |  |  |
Regulatory Milestones | Nonrecurring basis | Significant unobservable inputs (Level 3) |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Gain (loss) recognized on change in fair value on contingent consideration forfeited by Participating Rightholders |  |  | 1,000,000.0 |  |  |
Net Sales Milestones and Royalties | Recurring basis |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Contingent consideration payable |  | 100,600,000 | 101,200,000 |  |  |
Net Sales Milestones and Royalties | Recurring basis | Significant unobservable inputs (Level 3) |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Contingent consideration payable |  | $ 100,600,000 | 101,200,000 |  |  |
Agilis |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Net sales amount | $ 150,000,000.0 |  |  |  |  |
Agilis | Minimum |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Product sales (as a percent) | 2.00% | 2.00% |  |  |  |
Agilis | Maximum |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Development milestone payment obligations |  | $ 60,000,000.0 |  |  |  |
Priority review voucher amount |  | 535,000,000.0 |  |  |  |
Development milestone payment obligations, net of cancellation and forfeiture |  | 20,000,000.0 |  |  |  |
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture |  | 361,000,000.0 |  |  |  |
Net sales amount |  | $ 150,000,000.0 |  |  |  |
Product sales (as a percent) | 6.00% | 6.00% |  |  |  |
Agilis | Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Commitments |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Contingent consideration payable- net sales milestones and royalties |  | $ 139,300,000 | 139,200,000 | $ 290,500,000 |  |
Agilis | Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Commitments |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Contingent consideration payable- net sales milestones and royalties |  | 100,600,000 | 101,200,000 | $ 65,800,000 |  |
Non-collaborative Arrangement Transactions | Agilis |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Development milestone payment obligations |  | 40,000,000.0 | 40,000,000.0 |  |  |
Payments on deferred consideration obligation |  |  | 2,400,000 |  |  |
Rights Exchange Agreement |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Cash consideration payment under Rights Exchange Agreement |  |  | $ 36,900,000 |  |  |
Issuance of common stock related to rights exchange (in shares) |  |  | 2,821,176 |  |  |
Issuance of common stock related to rights exchange |  |  | $ 150,500,000 |  |  |
Transaction fees |  |  | 2,000,000.0 |  |  |
Rights Exchange Agreement | Development and Regulatory Milestones |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Contingent liability, cancellation and forfeiture | $ 211,600,000 |  |  |  |  |
Rights Exchange Agreement | Regulatory Milestones |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Amount of potential future milestone payments forfeited by Participating Rightholders |  |  | 174,000,000.0 |  |  |
Settled value of milestone payments |  |  | 139,200,000 |  |  |
Gain (loss) recognized on settlement of milestones |  |  | (11,300,000) |  |  |
Rights Exchange Agreement | Development Milestones |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Amount of potential future milestone payments forfeited by Participating Rightholders |  |  | 37,600,000 |  |  |
Settled value of milestone payments |  |  | 37,600,000 |  |  |
Gain (loss) recognized on settlement of milestones |  |  | $ 700,000 |  |  |
Rights Exchange Agreement | Agilis |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |
Contingent liability, cancellation and forfeiture |  | $ 211,600,000 |  |  |  |

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