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Summary of significant accounting policies - Narrative (Details) $ in Thousands | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Jul. 31, 2020 USD ($) | Dec. 31, 2021 USD ($) segment | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Letters of Credit |  |  |  | $ 7,500 |
Number of operating segments | segment |  | 1 |  |  |
Number of reporting units | segment |  | 1 |  |  |
Allowance for credit loss |  | $ 0 | $ 0 |  |
Allowance for doubtful accounts receivable |  | 100 | 100 |  |
Unrealized foreign exchange gain on translation of intercompany loan |  | 41,000 |  |  |
Revenue |  | 538,593 | 380,766 | 306,980 |
Deferred payroll taxes provided for under CARES Act |  |  | 1,300 |  |
Cash consideration received from Royalty Purchase Agreement | $ 650,000 |  | 650,000 |  |
State income tax provision |  | $ 3,844 | $ 24,984 | $ 61 |
Federal income tax statutory rate |  | 21.00% | 21.00% | 21.00% |
Deferred tax liability |  | $ 137,659 | $ 169,265 |  |
Impairment of long-lived assets |  | 0 |  |  |
Impairment of indefinite-lived intangibles excluding goodwill |  | 0 |  |  |
Impairment of goodwill |  | 0 |  |  |
Minimum |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Term for letter of credit (in years) |  |  |  | 5 years |
Agilis |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Deferred tax liability |  |  |  |  | $ 122,000
Impairment of goodwill |  | 0 |  |  |
Prepaids and other current assets |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Deferred research and development advance payments, short-term |  | 1,400 | 4,700 |  |
Deposits and other assets |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Deferred research and development advance payments, long-term |  | 1,800 | 1,600 |  |
Fifth Anniversary |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Letters of Credit |  |  |  | $ 3,800 |
Term for letter of credit (in years) |  |  |  | 5 years |
Non-US |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Revenue |  | 241,588 | 194,370 |  |
United States |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Revenue |  | 297,005 | 186,396 |  |
Net product revenue |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Revenue |  | 428,904 | 333,401 | $ 291,306 |
Net product revenue | Non-US |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Revenue |  | 241,600 | 194,400 | 190,300 |
Emflaza | United States |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Revenue |  | 187,300 | 139,000 | 101,000 |
Translarna | Non-US |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |
Revenue |  | $ 236,000 | $ 191,900 | $ 190,000 |

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