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Income taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Deferred tax assets: |  |
Accrued expense | $ 8,208 | $ 5,528
Amortization | 87,998 | 80,677
Federal tax credits | 142,595 | 123,405
State tax credits | 8,054 |
Federal net operating losses | 76,589 | 16,999
State net operating losses | 9,159 | 1,428
Foreign net operating losses | 3,316 |
Capitalized research and development costs | 241 | 661
Share based compensation and other | 15,273 | 14,612
Liability for sale of future royalties | 148,503 | 161,204
Noncash interest expense | 26,040 |
Other comprehensive loss | 143 | 7,624
Total gross deferred tax assets | 526,119 | 412,138
Less valuation allowance | (525,570) | (379,608)
Total deferred tax assets, net of valuation allowance | 549 | 32,530
Deferred tax liabilities: |  |
Depreciation | (549) | (2,904)
Convertible debt |  | (29,626)
Indefinite lived intangible | (137,110) | (136,735)
Total gross deferred tax liabilities | (137,659) | (169,265)
Net deferred tax assets (liabilities) | $ (137,110) | $ (136,735)

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