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Revenue recognition - Collaboration and Royalty Revenue (Details) $ in Thousands | 1 Months Ended | 12 Months Ended |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 31, 2021 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) payment | Dec. 31, 2019 USD ($) | Aug. 31, 2021 USD ($) | Mar. 31, 2021 USD ($) | Oct. 31, 2020 USD ($) | Aug. 31, 2020 USD ($) | Nov. 30, 2019 USD ($) | Nov. 30, 2011 USD ($)
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved | $ 300,000 | $ 300,000 |  |  |  |  |  |  |  |
Revenue |  | 538,593 | $ 380,766 | $ 306,980 |  |  |  |  |  |
Collaboration revenue |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Revenue |  | 55,046 | 42,579 | 15,674 |  |  |  |  |  |
Royalty revenue |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Revenue |  | 54,643 | 4,786 |  |  |  |  |  |  |
SMA License Agreement | Collaboration revenue |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Revenue |  | 55,000 | 42,600 | 15,200 |  |  |  |  |  |
SMA License Agreement | Royalty revenue |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Revenue |  | 54,600 | $ 4,800 | $ 0 |  |  |  |  |  |
Research and Development and Sales Milestones | Collaboration revenue |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Number of milestone payments. | payment |  |  | 3 |  |  |  |  |  |  |
Research And Development Event Milestones | SMA License Agreement |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved | 0 | 0 |  |  |  |  |  |  |  |
Milestone payments received |  |  |  |  | $ 10,000 | $ 20,000 | $ 7,500 |  | $ 15,000 |
Research And Development Event Milestones, Period Payment 1 | SMA License Agreement |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Milestone payments received |  |  |  |  |  |  |  | $ 20,000 |  |
Research And Development Event Milestones, Period Payment 2 | SMA License Agreement |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Milestone payments received |  |  |  |  |  |  |  | $ 15,000 |  |
Sales Milestones | SMA License Agreement |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved | 300,000 | 300,000 |  |  |  |  |  |  |  |
Net sales milestone threshold achieved |  | $ 500,000 |  |  |  |  |  |  |  |
Sales Milestones | SMA License Agreement | Prepaids and other current assets |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Milestone payments due | $ 25,000 |  |  |  |  |  |  |  |  |
Maximum | Research And Development Event Milestones | SMA License Agreement | Roche |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  |  |  |  |  |  |  | $ 135,000
Maximum | Sales Milestones | SMA License Agreement | Roche |  |  |  |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  |  |  |  |  |  |  | $ 325,000

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