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Stock award plan - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Dec. 31, 2020 | May 31, 2013 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Jun. 30, 2021 | May 31, 2021 | Jan. 31, 2020
Stock option plan |  |  |  |  |  |  |  |
Share-based compensation expense |  |  | $ 103,513 | $ 70,325 | $ 42,134 |  |  |
Unrecognized compensation cost |  |  | $ 198,800 |  |  |  |  |
Weighted average remaining service period for recognition of unrecognized compensation cost |  |  | 2 years 6 months 14 days |  |  |  |  |
Unvested restricted stock |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Granted (in shares) |  |  | 1,018,228 |  |  |  |  |
Forfeited (in shares) |  |  | 145,341 |  |  |  |  |
Stock option |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Granted (in shares) |  |  | 2,487,234 | 2,777,975 | 3,977,995 |  |  |
Forfeited (in shares) |  |  | 742,458 | 889,785 | 518,527 |  |  |
Expected dividend yield (as a percent) |  |  | 0.00% | 0.00% | 0.00% |  |  |
Weighted average grant date fair value (in dollars per share) |  |  | $ 43.05 | $ 36.94 | $ 23.05 |  |  |
Stock option | Maximum |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Vesting period |  |  | 4 years |  |  |  |  |
Employee Stock [Member] |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Number of shares authorized (in shares) |  |  |  |  |  | 2,000,000 | 1,000,000 |
Award requisite service period |  |  | 6 months |  |  |  |  |
Share-based compensation expense |  |  | $ 2,300 |  |  |  |  |
Employee Stock [Member] | Minimum |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Purchase price of common stock, percent |  |  | 85.00% |  |  |  |  |
Employee stock purchase plan, voting percentage limit |  |  | 5.00% |  |  |  |  |
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Number of shares available for issuance |  |  | 0 |  |  |  |  |
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Maximum |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Number of shares subject to outstanding awards (in shares) |  | 3,040,444 |  |  |  |  |  |
2009 Equity and Long Term Incentive Plan and 2013 Stock Incentive Plan |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Number of shares available for issuance |  | 122,296 |  |  |  |  |  |
2013 Long Term Incentive Plan |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Number of shares available for issuance |  |  | 995,368 |  |  |  |  |
Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase Number |  | 2,500,000 |  |  |  |  |  |
Annual increase in the number of shares outstanding on the first day of the fiscal year |  | 4.00% |  |  |  |  |  |
2020 Inducement Stock Incentive Plan |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Number of shares available for issuance |  |  | 794,436 |  |  |  |  |
Number of additional shares authorized (in shares) | 1,000,000 |  |  |  |  |  |  |
2020 Inducement Stock Incentive Plan | Maximum |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Number of shares authorized (in shares) |  |  |  |  |  |  |  | 1,000,000
2020 Inducement Stock Incentive Plan | Stock option |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Granted (in shares) |  |  | 392,845 |  |  |  |  |
Stockholder's specified ownership percentage |  |  | 10.00% |  |  |  |  |
Expiration period |  |  | 10 years |  |  |  |  |
Granted (in dollars per share) |  |  | $ 42.32 |  |  |  |  |
Forfeited (in shares) |  |  | 335,020 |  |  |  |  |
2020 Inducement Stock Incentive Plan | Stock option | Minimum |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date |  |  | 100.00% |  |  |  |  |
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date |  |  | 110.00% |  |  |  |  |
2020 Inducement Stock Incentive Plan | Restricted stock units |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |
Granted (in shares) |  |  | 128,635 |  |  |  |  |
Forfeited (in shares) |  |  | 14,810 |  |  |  |  |

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- Definition The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(1) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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