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Commitments and contingencies - Narrative (Details) - USD ($) $ in Millions | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | ---
Dec. 31, 2021 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2020 | May 29, 2020 | Apr. 29, 2020 | Apr. 20, 2017 | Jun. 30, 2016
Akcea |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Upfront licensing fee |  | $ 6.0 | $ 12.0 |  |  |  |  |
Milestone payments |  | $ 4.0 |  |  |  |  |  |
Akcea | Maximum |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Milestone payments | $ 4.0 |  |  |  |  |  |  |
Censa [Member] |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Asset acquisition, milestone, amount |  |  |  |  | $ 217.5 |  |  |
Asset acquisition, development and regulatory milestones |  |  |  |  | 109.0 |  |  |
Asset acquisition, net sales milestone |  |  |  |  | 160.0 |  |  |
Asset acquisition, initial milestone |  |  |  |  | $ 30.0 |  |  |
Agilis Merger Agreement | Marathon Pharmaceuticals, LLC |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Development milestone payment obligations |  |  |  |  |  |  | $ 50.0 |
SMA License Agreement | Maximum |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Potential royalty payments due on net product sales | 52.5 |  |  |  |  |  |  |
Agilis |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay | 40.0 |  |  |  |  |  |  |
Net sales amount |  |  |  |  |  | $ 150.0 |  |
Development milestone obligation payments made | $ 2.4 |  |  |  |  |  |  |
Agilis | Minimum |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Product sales (as a percent) | 2.00% |  |  |  |  | 2.00% |  |
Agilis | Maximum |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Development milestone payment obligations | $ 60.0 |  |  |  |  |  |  |
Priority review voucher amount | 535.0 |  |  |  |  |  |  |
Net sales amount | $ 150.0 |  |  |  |  |  |  |
Product sales (as a percent) | 6.00% |  |  |  |  | 6.00% |  |
Development milestone payment obligations, net of cancellation and forfeiture | $ 20.0 |  |  |  |  |  |  |
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture | 361.0 |  |  |  |  |  |  |
Agilis | Agilis Merger Agreement |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Development milestone payment obligations | 40.0 |  |  | $ 40.0 |  |  |  |
Agilis | Rights Exchange Agreement |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Contingent liability cancellation and forfeiture of potential milestone payments | 174.0 |  |  |  |  |  |  |
Development milestone payment obligations, cancellation and forfeiture | 37.6 |  |  |  |  |  |  |
Contingent liability, cancellation and forfeiture | 211.6 |  |  |  |  |  |  |
BioElectron | Maximum |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Development milestone payment obligations | 200.0 |  |  |  |  |  |  |
Net product revenue | Wellcome trust |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Development milestone payment obligations |  |  |  |  |  |  |  | $ 0.8
Net product revenue | Wellcome trust | Maximum |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |
Development milestone payment obligations | $ 22.4 |  |  |  |  |  |  |

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