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Fair value of financial instruments and investments - Marketable Securities, Unrealized Gains (Losses) (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost | $ 377,287 | $ 892,938
Gross Unrealized, Gain | 107 | 1,975
Gross Unrealized, Loss | (709) | (75)
Fair Value | 376,685 | 894,838
Write downs of available for sale debt securities | 0 | 0
Increase in allowance for credit losses | 0 | 0
Realized gain (loss) from sale of marketable securities | 800 | 700
Commercial paper |  |
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost | 75,275 | 276,855
Gross Unrealized, Gain | 5 | 19
Gross Unrealized, Loss | (1) | (37)
Fair Value | 75,279 | 276,837
Corporate debt securities |  |
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost | 268,246 | 474,030
Gross Unrealized, Gain | 81 | 1,658
Gross Unrealized, Loss | (644) | (29)
Fair Value | 267,683 | 475,659
Asset-backed securities |  |
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost | 15,287 | 28,681
Gross Unrealized, Gain | 16 | 210
Gross Unrealized, Loss | (5) | (3)
Fair Value | 15,298 | 28,888
Government obligations |  |
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost | 18,479 | 113,372
Gross Unrealized, Gain | 5 | 88
Gross Unrealized, Loss | (59) | (6)
Fair Value | $ 18,425 | $ 113,454

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- Definition Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123581744&loc=d3e27161-111563 + Details
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