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Income taxes (Tables) | 12 Months Ended
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Dec. 31, 2021
Income Tax Disclosure [Abstract] |
Schedule of Income before Income Tax, Domestic and Foreign | The loss from operations before tax (expense) benefit consisted of the following for the years ended December 31, 2021, 2020, and 2019: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2021 |  | 2020 |  | 2019
Domestic | ​ | $ | (487,726) | ​ | $ | (452,475) | ​ | $ | (231,915)
Foreign | ​ |  | (30,614) | ​ |  | 49,543 | ​ |  | (8,011)
Total | ​ | $ | (518,340) | ​ | $ | (402,932) | ​ | $ | (239,926)
​
Components of Income Tax Provision | The Income Tax Provision consisted of the following for the years ended December 31, 2021, 2020 and 2019: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2021 |  | 2020 |  | 2019
Current: |  | ​ |  |  | ​ |  |  | ​ |
U.S. Federal | ​ | $ | — | ​ | $ | — | ​ | $ | —
U.S. State and Local | ​ |  | (3,844) | ​ |  | (24,984) | ​ |  | (61)
Foreign | ​ |  | (1,340) | ​ |  | (4,372) | ​ |  | (2,041)
Deferred: | ​ |  |  | ​ |  |  | ​ |  |
U.S. Federal | ​ |  | — | ​ |  | — | ​ |  | —
U.S. State and Local | ​ |  | (377) | ​ |  | (5,872) | ​ |  | (8,812)
Foreign | ​ |  | — | ​ |  | — | ​ |  | (736)
Total tax expense | ​ | $ | (5,561) | ​ | $ | (35,228) | ​ | $ | (11,650)
Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate | A reconciliation of the U.S. statutory income tax rate to the Company’s effective tax rate is as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | December 31, |
​ |  | 2021 |  | 2020 |  | 2019 |
Federal income tax provision at statutory rate | ​ | 21.00 | % | 21.00 | % | 21.00 | %
State income tax provision, net of federal benefit | ​ | (0.74) |  | (3.31) |  | 1.08 |
Permanent differences | ​ | (4.06) |  | (6.66) |  | (6.17) |
Research and development | ​ | 4.50 |  | 4.93 |  | 4.38 |
Change in valuation allowances | ​ | (29.03) |  | (26.40) |  | (35.49) |
Change in deferred tax assets | ​ | 12.05 |  | 2.93 |  | 15.89 |
Foreign tax rate differential | ​ | 0.01 |  | 0.72 |  | (1.88) |
Tax rate change | ​ | 0.01 |  | (1.46) |  | (3.67) |
(Accrual) Release of uncertain tax positions | ​ | (4.78) | ​ | (0.61) | ​ | — | ​
Other | ​ | (0.03) |  | 0.12 |  | — |
Effective income tax rate | ​ | (1.07) | % | (8.74) | % | (4.86) | %
​
Schedule of significant components of the Company's deferred tax assets and liabilities | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | December 31,
​ | ​ | 2021 |  | 2020
Assets: |  | ​ |  |  | ​ |
Noncurrent deferred income taxes | ​ | $ | — | ​ | $ | —
Liabilities: | ​ |  |  | ​ |  |
Noncurrent deferred income taxes | ​ |  | (137,110) | ​ |  | (136,735)
Deferred income taxes - net | ​ | $ | (137,110) | ​ | $ | (136,735)
​ The significant components of the Company’s deferred tax assets and liabilities at December 31, 2021 and 2020 are as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2021 |  | 2020
Deferred tax assets: |  | ​ |  |  | ​ |
Accrued expense | ​ | $ | 8,208 | ​ | $ | 5,528
Amortization | ​ |  | 87,998 | ​ |  | 80,677
Depreciation | ​ |  | — | ​ |  | —
Federal tax credits | ​ |  | 142,595 | ​ |  | 123,405
State tax credits | ​ |  | 8,054 | ​ |  | —
Federal net operating losses | ​ |  | 76,589 | ​ |  | 16,999
State net operating losses | ​ |  | 9,159 | ​ |  | 1,428
Foreign net operating losses | ​ |  | 3,316 | ​ |  | —
Capitalized research and development costs | ​ |  | 241 | ​ |  | 661
Share based compensation and other | ​ |  | 15,273 | ​ |  | 14,612
Liability for sale of future royalties | ​ | ​ | 148,503 | ​ | ​ | 161,204
Noncash interest expense | ​ | ​ | 26,040 | ​ | ​ | —
Other comprehensive loss | ​ |  | 143 | ​ |  | 7,624
Total gross deferred tax assets | ​ |  | 526,119 | ​ |  | 412,138
Less valuation allowance | ​ |  | (525,570) | ​ |  | (379,608)
Total deferred tax assets, net of valuation allowance | ​ | $ | 549 | ​ | $ | 32,530
Deferred tax liabilities: | ​ |  |  | ​ |  |
Depreciation | ​ | $ | (549) | ​ | $ | (2,904)
Convertible debt | ​ | ​ | — | ​ | ​ | (29,626)
Indefinite lived intangible | ​ |  | (137,110) | ​ |  | (136,735)
Total gross deferred tax liabilities | ​ |  | (137,659) | ​ |  | (169,265)
Net deferred tax assets (liabilities) | ​ | $ | (137,110) | ​ | $ | (136,735)
​
Schedule of unrecognized tax benefits | A reconciliation of the gross amount of unrecognized tax benefits, excluding accrued interest and penalties, is as follows:
​ | ​ | ​
​ | Unrecognized Tax Benefits
Balance at December 31, 2020 | ​ | 2,446
Additions based on tax positions related to the current year |  | 24,771
Balance at December 31, 2021 | $ | 27,217

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