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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - Commitments - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020
Development and Regulatory Milestones |  |
Changes in the fair value of warrant liability and SARs liability |  |
Beginning Balance | $ 139,200 | $ 290,500
Change in fair value | 100 | (12,120)
Rights Exchange settlement |  | (139,180)
Ending Balance | 139,300 | 139,200
Liability, Net Sales Milestones and Royalties [Member] |  |
Changes in the fair value of warrant liability and SARs liability |  |
Beginning Balance | 101,200 | 65,800
Change in fair value | (600) | 35,400
Ending Balance | $ 100,600 | $ 101,200

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