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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Revenues:      
Revenue $ 538,593 $ 380,766 $ 306,980
Operating expenses:      
Cost of product sales, excluding amortization of acquired intangible assets 32,328 18,942 12,135
Amortization of intangible assets 54,751 36,892 27,650
Research and development 540,684 477,643 257,452
Selling, general and administrative 285,773 245,164 202,541
Change in the fair value of deferred and contingent consideration (500) 23,280 48,360
Settlement of deferred and contingent consideration   10,613  
Total operating expenses 913,036 812,534 548,138
Loss from operations (374,443) (431,768) (241,158)
Interest expense, net (86,022) (56,352) (12,491)
Other (expense) income, net (57,875) 85,188 13,723
Loss before income tax expense (518,340) (402,932) (239,926)
Income tax benefit (expense) (5,561) (35,228) (11,650)
Net loss attributable to common stockholders $ (523,901) $ (438,160) $ (251,576)
Weighted-average shares outstanding:      
Basic 70,466,393 66,027,908 58,863,185
Diluted 70,466,393 66,027,908 58,863,185
Net loss per share-basic and diluted (in dollars per share)      
Basic $ (7.43) $ (6.64) $ (4.27)
Diluted $ (7.43) $ (6.64) $ (4.27)
Net product revenue      
Revenues:      
Revenue $ 428,904 $ 333,401 $ 291,306
Collaboration revenue      
Revenues:      
Revenue 55,046 42,579 $ 15,674
Royalty revenue      
Revenues:      
Revenue $ 54,643 $ 4,786