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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
 1 Months Ended 12 Months Ended
Jul. 31, 2020
USD ($)
Dec. 31, 2021
USD ($)
segment
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Letters of Credit       $ 7,500  
Number of operating segments | segment   1      
Number of reporting units | segment   1      
Allowance for credit loss   $ 0 $ 0    
Allowance for doubtful accounts receivable   100 100    
Unrealized foreign exchange gain on translation of intercompany loan   41,000      
Revenue   538,593 380,766 306,980  
Deferred payroll taxes provided for under CARES Act     1,300    
Cash consideration received from Royalty Purchase Agreement $ 650,000   650,000    
State income tax provision   $ 3,844 $ 24,984 $ 61  
Federal income tax statutory rate   21.00% 21.00% 21.00%  
Deferred tax liability   $ 137,659 $ 169,265    
Impairment of long-lived assets   0      
Impairment of indefinite-lived intangibles excluding goodwill   0      
Impairment of goodwill   0      
Minimum          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Term for letter of credit (in years)       5 years  
Agilis          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Deferred tax liability         $ 122,000
Impairment of goodwill   0      
Prepaids and other current assets          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Deferred research and development advance payments, short-term   1,400 4,700    
Deposits and other assets          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Deferred research and development advance payments, long-term   1,800 1,600    
Fifth Anniversary          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Letters of Credit       $ 3,800  
Term for letter of credit (in years)       5 years  
Non-US          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Revenue   241,588 194,370    
United States          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Revenue   297,005 186,396    
Net product revenue          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Revenue   428,904 333,401 $ 291,306  
Net product revenue | Non-US          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Revenue   241,600 194,400 190,300  
Emflaza | United States          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Revenue   187,300 139,000 101,000  
Translarna | Non-US          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Revenue   $ 236,000 $ 191,900 $ 190,000