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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - Commitments - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Development and Regulatory Milestones
Changes in the fair value of warrant liability and SARs liability
Beginning Balance	$ 139,200	$ 290,500
Change in fair value	100	(12,120)
Rights Exchange settlement		(139,180)
Ending Balance	139,300	139,200
Liability, Net Sales Milestones and Royalties [Member]
Changes in the fair value of warrant liability and SARs liability
Beginning Balance	101,200	65,800
Change in fair value	(600)	35,400
Ending Balance	$ 100,600	$ 101,200

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+ References

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- Definition

Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)
-URI http://asc.fasb.org/extlink&oid=123874694&loc=d3e19207-110258

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- Definition

Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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-Section 50
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- Definition

Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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-Publisher FASB
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-Section 50
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