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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Commitments $ in Thousands	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Valuation Technique, Discounted Cash Flow | Probability of Success [Member] | Weighted Average [Member]
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.42
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Weighted Average [Member]
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.034
Liability, Net Sales Milestones and Royalties [Member] | Significant unobservable inputs (Level 3) | Valuation Technique, Option Pricing Model | Probability of Success [Member] | Weighted Average [Member]
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.48
Liability, Net Sales Milestones and Royalties [Member] | Significant unobservable inputs (Level 3) | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate | Weighted Average [Member]
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.110
Agilis | Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum
Fair Value Valuation Inputs
Potential milestones	$ 0	$ 0
Agilis | Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 381,000	$ 381,000
Agilis | Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success [Member] | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.25	0.25
Agilis | Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success [Member] | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.94	0.94
Agilis | Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.017	0.022
Agilis | Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.047	0.045
Agilis | Development and Regulatory Milestones | Significant unobservable inputs (Level 3)
Fair Value Valuation Inputs
Fair value	$ 139,300	$ 139,200	$ 290,500
Agilis | Liability, Net Sales Milestones and Royalties [Member] | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum
Fair Value Valuation Inputs
Potential milestones	0	0
Agilis | Liability, Net Sales Milestones and Royalties [Member] | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 150,000	$ 150,000
Agilis | Liability, Net Sales Milestones and Royalties [Member] | Valuation Technique, Option Pricing Model | Probability of Success [Member] | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.25	0.25
Agilis | Liability, Net Sales Milestones and Royalties [Member] | Valuation Technique, Option Pricing Model | Probability of Success [Member] | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.94	0.94
Agilis | Liability, Net Sales Milestones and Royalties [Member] | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.02	0.02
Agilis | Liability, Net Sales Milestones and Royalties [Member] | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.06	0.06
Agilis | Liability, Net Sales Milestones and Royalties [Member] | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.110	0.115
Agilis | Liability, Net Sales Milestones and Royalties [Member] | Significant unobservable inputs (Level 3)
Fair Value Valuation Inputs
Fair value	$ 100,600	$ 101,200	$ 65,800

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- Definition

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+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=123874694&loc=d3e19207-110258

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