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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Dec. 31, 2020
May 31, 2013
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Jun. 30, 2021
May 31, 2021
Jan. 31, 2020
Stock option plan                
Share-based compensation expense     $ 103,513 $ 70,325 $ 42,134      
Unrecognized compensation cost     $ 198,800          
Weighted average remaining service period for recognition of unrecognized compensation cost     2 years 6 months 14 days          
Unvested restricted stock                
Stock option plan                
Granted (in shares)     1,018,228          
Forfeited (in shares)     145,341          
Stock option                
Stock option plan                
Granted (in shares)     2,487,234 2,777,975 3,977,995      
Forfeited (in shares)     742,458 889,785 518,527      
Expected dividend yield (as a percent)     0.00% 0.00% 0.00%      
Weighted average grant date fair value (in dollars per share)     $ 43.05 $ 36.94 $ 23.05      
Stock option | Maximum                
Stock option plan                
Vesting period     4 years          
Employee Stock [Member]                
Stock option plan                
Number of shares authorized (in shares)           2,000,000 1,000,000  
Award requisite service period     6 months          
Share-based compensation expense     $ 2,300          
Employee Stock [Member] | Minimum                
Stock option plan                
Purchase price of common stock, percent     85.00%          
Employee stock purchase plan, voting percentage limit     5.00%          
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan                
Stock option plan                
Number of shares available for issuance     0          
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Maximum                
Stock option plan                
Number of shares subject to outstanding awards (in shares)   3,040,444            
2009 Equity and Long Term Incentive Plan and 2013 Stock Incentive Plan                
Stock option plan                
Number of shares available for issuance   122,296            
2013 Long Term Incentive Plan                
Stock option plan                
Number of shares available for issuance     995,368          
Share based Compensation Arrangement by Share based Payment Award Number of Shares Authorized Annual Increase Number   2,500,000            
Annual increase in the number of shares outstanding on the first day of the fiscal year   4.00%            
2020 Inducement Stock Incentive Plan                
Stock option plan                
Number of shares available for issuance     794,436          
Number of additional shares authorized (in shares) 1,000,000              
2020 Inducement Stock Incentive Plan | Maximum                
Stock option plan                
Number of shares authorized (in shares)               1,000,000
2020 Inducement Stock Incentive Plan | Stock option                
Stock option plan                
Granted (in shares)     392,845          
Stockholder's specified ownership percentage     10.00%          
Expiration period     10 years          
Granted (in dollars per share)     $ 42.32          
Forfeited (in shares)     335,020          
2020 Inducement Stock Incentive Plan | Stock option | Minimum                
Stock option plan                
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date     100.00%          
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date     110.00%          
2020 Inducement Stock Incentive Plan | Restricted stock units                
Stock option plan                
Granted (in shares)     128,635          
Forfeited (in shares)     14,810