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Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Stock option plan
Share-based compensation expense	$ 103,513	$ 70,325	$ 42,134
Unrecognized compensation cost	$ 198,800
Weighted average remaining service period for recognition of unrecognized compensation cost	2 years 6 months 14 days
Research and development
Stock option plan
Share-based compensation expense	$ 53,632	38,716	20,836
Selling, general and administrative
Stock option plan
Share-based compensation expense	$ 49,881	$ 31,609	$ 21,298

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
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-Paragraph 1
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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

+ References

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- Definition

Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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