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Revenue recognition - Net Product Sales (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($) segment	Dec. 31, 2020 USD ($) Distributor	Dec. 31, 2019 USD ($) Distributor
Net product sales
Number of operating segments | segment	1
Revenue	$ 538,593	$ 380,766	$ 306,980
Number of distributors | Distributor		2	2
Contract with customer, liability		$ 4,200
Contract Assets		0	$ 0
Performance obligations satisfied in period		4,000	$ 8,100
United States
Net product sales
Revenue	297,005	186,396
Non-US
Net product sales
Revenue	241,588	$ 194,370
Maximum
Net product sales
Percentage of net product sales threshold		10.00%	10.00%
Net product revenue
Net product sales
Revenue	428,904	$ 333,401	$ 291,306
Net product revenue | Non-US
Net product sales
Revenue	241,600	194,400	190,300
Emflaza | United States
Net product sales
Revenue	187,300	139,000	101,000
Translarna | Non-US
Net product sales
Revenue	$ 236,000	$ 191,900	$ 190,000

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