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Commitments and contingencies - Narrative (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2020	May 29, 2020	Apr. 29, 2020	Apr. 20, 2017	Jun. 30, 2016
Akcea
Other Commitments
Upfront licensing fee		$ 6.0	$ 12.0
Milestone payments		$ 4.0
Akcea | Maximum
Other Commitments
Milestone payments	$ 4.0
Censa [Member]
Other Commitments
Asset acquisition, milestone, amount					$ 217.5
Asset acquisition, development and regulatory milestones					109.0
Asset acquisition, net sales milestone					160.0
Asset acquisition, initial milestone					$ 30.0
Agilis Merger Agreement | Marathon Pharmaceuticals, LLC
Other Commitments
Development milestone payment obligations							$ 50.0
SMA License Agreement | Maximum
Other Commitments
Potential royalty payments due on net product sales	52.5
Agilis
Other Commitments
Development milestone payments which the entity is obligated to pay	40.0
Net sales amount						$ 150.0
Development milestone obligation payments made	$ 2.4
Agilis | Minimum
Other Commitments
Product sales (as a percent)	2.00%					2.00%
Agilis | Maximum
Other Commitments
Development milestone payment obligations	$ 60.0
Priority review voucher amount	535.0
Net sales amount	$ 150.0
Product sales (as a percent)	6.00%					6.00%
Development milestone payment obligations, net of cancellation and forfeiture	$ 20.0
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture	361.0
Agilis | Agilis Merger Agreement
Other Commitments
Development milestone payment obligations	40.0			$ 40.0
Agilis | Rights Exchange Agreement
Other Commitments
Contingent liability cancellation and forfeiture of potential milestone payments	174.0
Development milestone payment obligations, cancellation and forfeiture	37.6
Contingent liability, cancellation and forfeiture	211.6
BioElectron | Maximum
Other Commitments
Development milestone payment obligations	200.0
Net product revenue | Wellcome trust
Other Commitments
Development milestone payment obligations								$ 0.8
Net product revenue | Wellcome trust | Maximum
Other Commitments
Development milestone payment obligations	$ 22.4

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- Definition

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