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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2022 | Mar. 31, 2021
Collaboration and royalty revenue |  |
Revenue | $ 148,735 | $ 117,942
Collaboration and grant revenue |  |
Collaboration and royalty revenue |  |
Revenue | 7 | 20,007
Royalty revenue |  |
Collaboration and royalty revenue |  |
Revenue | 18,896 | 6,655
SMA License Agreement | Collaboration and grant revenue |  |
Collaboration and royalty revenue |  |
Revenue | 0 | 20,000
SMA License Agreement | Royalty revenue |  |
Collaboration and royalty revenue |  |
Revenue | $ 18,900 | 6,700
SMA License Agreement | Sales Milestones |  |
Collaboration and royalty revenue |  |
Milestone payments received |  | $ 20,000

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