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v3.22.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Mar. 31, 2021
Cash flows from operating activities |  |
Net loss | $ (126,726) | $ (128,642)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 26,314 | 13,587
Non-cash operating lease expense | 1,908 | 1,819
Non-cash royalty revenue related to sale of future royalties | (8,113) | (2,858)
Non-cash interest expense on liability related to sale of future royalties | 18,874 | 18,080
Change in valuation of deferred and contingent consideration | (11,700) | 100
Unrealized loss (gain) on ClearPoint Equity Investments | 1,049 | (6,764)
Unrealized loss (gain) on ClearPoint convertible debt security | 1,542 | (7,858)
Unrealized gain on marketable securities - equity investments | 6,477 | 302
Amortization of premiums on investments, net | 887 | 1,359
Amortization of debt issuance costs | 464 | 452
Share-based compensation expense | 26,589 | 25,707
Disposal of asset | 79 |
Unrealized foreign currency transaction losses, net | 2,135 | 24,691
Changes in operating assets and liabilities: |  |
Inventory, net | 350 | 1,963
Prepaid expenses and other current assets | 25,118 | 15,605
Trade and royalty receivables, net | (28,372) | (25,010)
Deposits and other assets | (510) | 136
Accounts payable and accrued expenses | (30,680) | (28,756)
Other liabilities | (3,089) | (1,916)
Deferred revenue |  | (2,154)
Net cash used in operating activities | (97,404) | (100,157)
Cash flows from investing activities |  |
Purchases of fixed assets | (9,312) | (5,669)
Purchases of marketable securities - available for sale | (39,035) | (141,985)
Purchases of marketable securities - equity investments |  | (200,000)
Sale and redemption of marketable securities- available for sale | 167,101 | 392,093
Sale and redemption of marketable securities - equity investments | 2,423 |
Acquisition of product rights and licenses | (72,134) | (14,192)
Purchase of equity investment in ClearPoint |  | (100)
Net cash provided by investing activities | 49,043 | 30,147
Cash flows from financing activities |  |
Proceeds from exercise of options | 2,444 | 11,755
Payment of finance lease principal | (1,276) | (2,224)
Net cash provided by financing activities | 1,168 | 9,531
Effect of exchange rate changes on cash | 1,653 | (1,701)
Net decrease in cash and cash equivalents | (45,540) | (62,180)
Cash and cash equivalents, and restricted cash beginning of period | 197,218 | 216,312
Cash and cash equivalents, and restricted cash end of period | 151,678 | 154,132
Supplemental disclosure of cash information |  |
Cash paid for interest | 6,130 | 5,182
Cash paid for income taxes | 1,987 | 687
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized loss on marketable securities, net of tax | (2,913) | (1,294)
Right-of-use assets obtained in exchange for operating lease obligations | 587 | 13
Acquisition of product rights and licenses | $ 12,589 | $ 8,870

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