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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Agilis - Commitments $ in Thousands | Mar. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Mar. 31, 2021 USD ($) | Dec. 31, 2020 USD ($)
--- | --- | --- | --- | ---
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | $ 0 | $ 0 |  |
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | $ 381,000 | $ 381,000 |  |
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.25 | 0.25 |  |
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.94 | 0.94 |  |
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.42 |  |  |
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.038 | 0.017 |  |
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.061 | 0.047 |  |
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Weighted Average |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.051 |  |  |
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Fair value | $ 134,700 | $ 139,300 | $ 139,300 | $ 139,200
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | 0 | 0 |  |
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | $ 150,000 | $ 150,000 |  |
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.25 | 0.25 |  |
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.94 | 0.94 |  |
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.48 |  |  |
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.02 | 0.02 |  |
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.06 | 0.06 |  |
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.120 | 0.110 |  |
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate | Weighted Average |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.120 |  |  |
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Fair value | $ 93,500 | $ 100,600 | $ 101,200 | $ 101,200

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