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Fair value of financial instruments and marketable securities - Narrative (Details) | 1 Months Ended | 3 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | ---
Aug. 31, 2021 USD ($) | Feb. 28, 2021 USD ($) fund $ / shares | Jan. 31, 2020 USD ($) $ / shares | May 31, 2019 USD ($) $ / shares | Mar. 31, 2022 USD ($) | Mar. 31, 2021 USD ($) | Dec. 31, 2021 USD ($) | Apr. 29, 2020 USD ($) | Sep. 30, 2019 USD ($) | Aug. 31, 2015 USD ($)
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Write downs of available for sale debt securities |  |  |  |  | $ 0 |  |  |  |  |
Realized gain (loss) from sale of marketable securities |  |  |  |  | (100,000) | $ 700,000 |  |  |  |
Increase in allowance for credit losses |  |  |  |  | 0 | 0 |  |  |  |
Purchase of equity investments |  |  |  |  |  | 100,000 |  |  |  |
Unrealized gain (loss) on ClearPoint Equity Investment |  |  |  |  | (1,049,000) | 6,764,000 |  |  |  |
Purchase of convertible note |  |  |  |  | 39,035,000 | 141,985,000 |  |  |  |
Unrealized gain (loss) on convertible note |  |  |  |  | (1,542,000) | 7,858,000 |  |  |  |
Purchase of marketable securities - equity investments |  |  |  |  |  | 200,000,000 |  |  |  |
Redemption of marketable securities- equity investments |  |  |  |  | 2,423,000 |  |  |  |  |
Transfers of assets measured between Level 1, Level 2, and Level 3 |  |  |  |  | 0 |  | $ 0 |  |  |
Operating Expenses |  |  |  |  | 235,257,000 | 216,090,000 |  |  |  |
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset |  |  |  |  | 11,700,000 | (100,000) |  |  |  |
3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Principal |  |  |  |  | 150,000,000 |  | 150,000,000 |  |  | $ 150,000,000.0
Interest rate ( as a percent ) |  |  |  |  |  |  |  |  |  | 3.00%
Fair value of convertible notes |  |  |  |  | 155,700,000 |  | 158,300,000 |  |  |
1.50% Convertible senior notes due 2026 | Convertible debt |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Principal |  |  |  |  | $ 287,500,000 |  | 287,500,000 |  | $ 287,500,000 |
Interest rate ( as a percent ) |  |  |  |  | 1.50% |  |  |  | 1.50% |
Fair value of convertible notes |  |  |  |  | $ 287,500,000 |  | 305,300,000 |  |  |
Agilis |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  | $ 40,000,000.0 |  |  | $ 40,000,000.0 |  |
Agilis | Minimum |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Product sales (as a percent) |  |  |  |  | 2.00% |  |  |  |  |
Agilis | Maximum |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Product sales (as a percent) |  |  |  |  | 6.00% |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  | $ 60,000,000.0 |  |  |  |  |
Priority review voucher amount |  |  |  |  | 535,000,000.0 |  |  |  |  |
Net sales amount |  |  |  |  | 150,000,000.0 |  |  |  |  |
Recurring basis |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Fair value of convertible debt |  |  |  |  | 19,429,000 |  | 20,971,000 |  |  |
ClearPoint equity investment |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Purchase of equity investments |  | $ 100,000 |  | $ 4,000,000.0 |  |  |  |  |  |
Share price (in USD per share) | $ / shares |  | $ 23.50 |  | $ 3.10 |  |  |  |  |  |
Unrealized gain (loss) on ClearPoint Equity Investment |  |  |  |  | (1,000,000.0) | 6,800,000 |  |  |  |
Marketable securities - equity investments |  |  |  |  | 13,500,000 |  | 14,500,000 |  |  |
ClearPoint convertible debt |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Purchase of convertible debt investment |  |  | $ 10,000,000.0 |  |  |  |  |  |  |
Conversion price - convertible note | $ / shares |  |  | $ 6.00 |  |  |  |  |  |  |
Unrealized gain (loss) on convertible note |  |  |  |  | (1,500,000) | 7,900,000 |  |  |  |
Fair value of convertible debt |  |  |  |  | 19,400,000 |  | $ 21,000,000.0 |  |  |
Mutual Funds |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Purchase of marketable securities - equity investments |  | $ 200,000,000.0 |  |  |  |  |  |  |  |
Number of mutual funds invested in | fund |  | 2 |  |  |  |  |  |  |  |
Redemption of marketable securities- equity investments |  |  |  |  | 2,400,000 | 0.0 |  |  |  |
Unrealized loss on marketable securities - equity investments |  |  |  |  | 6,500,000 | 300,000 |  |  |  |
Unrealized foreign currency transaction losses, net |  |  |  |  | $ 700,000 | $ (0.0) |  |  |  |
Mutual Fund, Purchase One |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Purchase of marketable securities - equity investments | $ 5,400,000 |  |  |  |  |  |  |  |  |
Mutual Fund, Purchase Two |  |  |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |  |  |
Purchase of marketable securities - equity investments | $ 4,600,000 |  |  |  |  |  |  |  |  |

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