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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 12 Months Ended | 43 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Apr. 20, 2017 | Aug. 31, 2021 | Dec. 31, 2019 | May 31, 2019 | Mar. 31, 2022 | Mar. 31, 2021 | Dec. 31, 2018 | Dec. 31, 2019 | Mar. 31, 2022 | Dec. 31, 2021 | Apr. 29, 2020 | Aug. 23, 2018
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Amortization of intangible assets |  |  |  |  | $ 23,473 | $ 11,278 |  |  |  |  |  |
Total allocation of IPR&D assets |  |  |  |  | 576,500 |  |  |  |  |  |  |
Change in indefinite-lived intangibles |  |  |  |  |  |  |  |  | $ 0 |  |  |
Accrued royalties |  |  |  |  | 30,670 |  |  |  | 30,670 | $ 35,679 |  |
Goodwill |  |  |  |  | 82,341 |  |  |  | 82,341 | $ 82,341 |  |
Changes in goodwill |  |  |  |  |  |  |  |  | 0 |  |  |
Tegsedi |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments |  |  |  |  | $ 400 | 0 |  |  |  |  |  |
Accrued royalties |  |  |  |  |  | 500 |  |  |  |  |  |
Weighted Average [Member] |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Remaining amortization period |  |  |  |  | 2 years 2 months 12 days |  |  |  |  |  |  |
Akcea |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  | $ 4,000 |  |  |  |  |  |  |  |  |  |
Marathon |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments received |  |  |  |  | $ 50,000 |  |  |  | 50,000 |  |  |
Agilis |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  | 40,000 |  |  |  | 40,000 |  | $ 40,000 |
Goodwill |  |  |  |  |  |  |  |  |  |  |  | $ 82,300
Goodwill adjustment |  |  |  |  |  |  | $ 18,000 |  |  |  |  |
Agilis Merger Agreement | Akcea |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  |  | $ 4,000 | $ 6,000 | 4,000 |  |  | $ 6,000 |  |  |  |
Useful life |  |  | 10 years |  |  |  |  |  |  |  |  |
Agilis Merger Agreement | Marathon |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  | 50,000 |  |  |  | 50,000 |  |  |
Emflaza asset acquisition |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangibles | $ 148,400 |  |  |  |  |  |  |  |  |  |  |
Milestone obligation payments recorded |  |  |  |  | 62,100 | $ 8,900 |  |  |  |  |  |
Useful life | 7 years |  |  |  |  |  |  |  |  |  |  |
Emflaza asset acquisition | Accounts payable and accrued expenses |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payable |  |  |  |  | $ 12,100 |  |  |  | $ 12,100 |  |  |

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