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Commitments and contingencies - Narrative (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Apr. 29, 2020 | Aug. 31, 2021 | Dec. 31, 2019 | May 31, 2019 | Mar. 31, 2022 | Dec. 31, 2019 | Dec. 31, 2021 | May 29, 2020 | Jun. 30, 2016
Other Commitments |  |  |  |  |  |  |  |  |
Accrued royalties |  |  |  |  | $ 30,670 |  | $ 35,679 |  |
Akcea |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Upfront licensing fee |  |  |  |  | 12,000 |  |  |  |
Milestone payments |  | $ 4,000 |  |  |  |  |  |  |
Akcea | Maximum |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Milestone payments |  | $ 4,000 |  |  |  |  |  |  |
Censa |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Asset acquisition, development and regulatory milestones |  |  |  |  |  |  |  | $ 109,000 |
Asset acquisition, initial milestone |  |  |  |  |  |  |  | 30,000 |
Censa | Maximum |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Asset acquisition, milestone, amount |  |  |  |  |  |  |  | 217,500 |
Asset acquisition, net sales milestone |  |  |  |  |  |  |  | $ 160,000 |
Agilis Merger Agreement | Akcea |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Milestone payments |  |  | $ 4,000 | $ 6,000 | 4,000 | $ 6,000 |  |  |
SMA License Agreement |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Accrued royalties |  |  |  |  | 14,000 |  |  |  |
SMA License Agreement | Maximum |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Potential royalty payments due on net product sales |  |  |  |  | 52,500 |  |  |  |
Agilis |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay | $ 40,000 |  |  |  | 40,000 |  |  |  |
Development milestone obligation payments made |  |  |  |  | $ 2,400 |  |  |  |
Agilis | Minimum |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Product sales (as a percent) |  |  |  |  | 2.00% |  |  |  |
Agilis | Maximum |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  | $ 60,000 |  |  |  |
Priority review voucher amount |  |  |  |  | 535,000 |  |  |  |
Net sales amount |  |  |  |  | $ 150,000 |  |  |  |
Product sales (as a percent) |  |  |  |  | 6.00% |  |  |  |
Development milestone payment obligations, net of cancellation and forfeiture |  |  |  |  | $ 20,000 |  |  |  |
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture |  |  |  |  | 361,000 |  |  |  |
Agilis | Rights Exchange Agreement |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Contingent liability cancellation and forfeiture of potential milestone payments | 174,000 |  |  |  |  |  |  |  |
Development milestone payment obligations, cancellation and forfeiture | 37,600 |  |  |  |  |  |  |  |
Contingent liability, cancellation and forfeiture | $ 211,600 |  |  |  |  |  |  |  |
BioElectron | Maximum |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  | 200,000 |  |  |  |
Marathon | Agilis Merger Agreement |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  | 50,000 |  |  |  |
Net product revenue | Wellcome trust |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  |  |  |  |  | $ 800
Net product revenue | Wellcome trust | Maximum |  |  |  |  |  |  |  |  |
Other Commitments |  |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  | $ 22,400 |  |  |  |

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