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Stock award plan - (Tables)

3 Months Ended

Mar. 31, 2022

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​		​		​	​		Weighted-			​	​
​	​	​	​	Weighted-		​	average	​	​	Aggregate
​	​	​	​	average		​	remaining	​	​	intrinsic
​	​	Number of	​	exercise		​	contractual	​	​	value(in
​	​	options	​	price		​	term	​	​	thousands)
​	​	​	​	​	​	​	​		​	​	​
Outstanding at December 31, 2021		10,772,582	​	$	43.66				​	​
Granted		1,275,830	​	​	38.10				​	​
Exercised		(97,188)	​	​	25.15				​	​
Forfeited/Cancelled		(199,511)	​	​	49.92				​	​
Outstanding at March 31, 2022		11,751,713	​	$	43.11		6.97	years	​	$	38,075
Vested or Expected to vest at March 31, 2022		4,497,327	​	$	48.04		8.54	years	​	$	2,127
Exercisable at March 31, 2022		6,763,376	​	$	39.44		5.79	years	​	$	35,859

​

Schedule of assumptions used to estimate fair values of grants made on the date of grant

​

​	​	​
​		Three months ended
​		March 31, 2022
Risk-free interest rate		1.55%
Expected volatility		73.56%
Expected term		5.5 years

Summary of information on the Company's restricted stock

​

​	​	​	​	​	​
​	​	Restricted Stock Awards and Units
​	​	​	​	Weighted
​	​	​	​	Average
​	​	​	​	Grant
​	​	Number of	​	Date
​		Shares		Fair Value
Unvested at December 31, 2021	​	1,519,831	​	$	55.43
Granted		1,490,190	​	​	38.10
Vested		(426,470)	​	​	51.26
Forfeited		(68,570)	​	​	48.45
Unvested at March 31, 2022		2,514,981	​	$	46.06

Schedule of share-based compensation expense recorded in the statement of operations

​

​	​	​	​	​	​	​	​
​	​	Three Months Ended March 31,					​
​		2022			2021		​
Research and development	​	$	13,034	​	$	13,725	​
Selling, general and administrative	​		13,555	​		11,982	​
Total	​	$	26,589	​	$	25,707	​

​

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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