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Debt - (Tables)

3 Months Ended

Mar. 31, 2022

Debt Instrument, Redemption [Line Items]

Summary of liability for sale of future royalties

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​	​	​	​	​
​		Three Months Ended March 31,		​
Liability for sale of future royalties- (current and noncurrent)	​	2022		​
Beginning balance as of December 31, 2021	​	$	733,985	​
Less: Non-cash royalty revenue payable to RPI	​	​	(8,113)	​
Plus: Non-cash interest expense recognized	​	​	18,874	​
Ending balance	​	$	744,746	​
Effective interest rate as of March 31, 2022	​		10.1	%

1.50% Convertible senior notes due 2026

Debt Instrument, Redemption [Line Items]

Summary of convertible notes

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​	​	​	​	​	​	​	​
​		​	​	​	​	​	​
Liability component	​	March 31, 2022		​	December 31, 2021		​
Principal	​	$	287,500	​	$	287,500	​
Less: Debt issuance costs	​		(5,324)	​		(5,606)	​
Net carrying amount	​	$	282,176	​	$	281,894	​

Summary of interest expense recognized related to the Convertible Notes

​

​	​	​	​	​	​	​	​
​		​	​	​	​	​
​	​	Three Months Ended March 31,
​	​	2022			​	2021	​
Contractual interest expense	​	$	1,069	​	$	1,069	​
Amortization of debt issuance costs	​	​	283	​	​	277	​
Total	​	$	1,352	​	$	1,346	​
Effective interest rate of the liability component	​	​	1.9	%	​	1.9	%

3.00% Convertible senior notes due 2022

Debt Instrument, Redemption [Line Items]

Summary of convertible notes

​

​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​
Liability component		March 31, 2022			December 31, 2021		​
Principal	​	$	150,000	​	$	150,000	​
Less: Debt issuance costs	​		(279)	​		(460)	​
Net carrying amount	​	$	149,721	​	$	149,540	​

Summary of interest expense recognized related to the Convertible Notes

​

​	​	​	​	​	​	​	​
​	​	​	​	​	​		​
​	Three Months Ended March 31,						​
​	2022			2021			​
Contractual interest expense	$	1,110	​	$	1,110	​	​
Amortization of debt issuance costs		181	​		175	​	​
Total	$	1,291	​	$	1,285	​	​
Effective interest rate of the liability component		3.5	%		3.5	%	​

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