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The Company (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2022 USD ($) product	Dec. 31, 2021 USD ($)	Sep. 30, 2019	Aug. 31, 2015
Long-term debt
Number of products | product	2
Retained earnings (accumulated deficit) | $	$ (2,224,683)	$ (2,097,957)
Convertible debt | 1.50% Convertible senior notes due 2026
Long-term debt
Interest rate ( as a percent )	1.50%		1.50%
Convertible debt | 3.00% Convertible senior notes due 2022
Long-term debt
Interest rate ( as a percent )				3.00%

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