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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
3 Months Ended
Jul. 17, 2020
USD ($)
Dec. 22, 2017
Mar. 31, 2022
USD ($)
segment
Mar. 31, 2021
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]            
Letters of Credit     $ 7,500      
Term for letter of credit (in years)     5 years      
Number of operating segments | segment     1      
Allowance for credit loss     $ 0      
Increase in allowance for credit losses     0 $ 0    
Allowance for doubtful accounts receivable     100   $ 100  
Revenue     148,735 117,942    
Deferred payroll taxes provided for under CARES Act     1,300      
Cash consideration received from Royalty Purchase Agreement $ 650,000          
Income taxes            
Federal income tax statutory rate   21.00%        
Federal income tax provision - IRC Section 174 R&D Expenses     600      
State income tax provision - IRC Section 174 R&D Expenses     $ 2,600      
Minimum            
New Accounting Pronouncements or Change in Accounting Principle [Line Items]            
Term for letter of credit (in years)     5 years      
Agilis            
Income taxes            
Deferred tax liability           $ 122,000
Fifth Anniversary            
New Accounting Pronouncements or Change in Accounting Principle [Line Items]            
Letters of Credit     $ 3,800      
Net product revenue            
New Accounting Pronouncements or Change in Accounting Principle [Line Items]            
Revenue     129,832 91,280    
Net product revenue | Non-US            
New Accounting Pronouncements or Change in Accounting Principle [Line Items]            
Revenue     81,200 47,800    
Emflaza | United States            
New Accounting Pronouncements or Change in Accounting Principle [Line Items]            
Revenue     48,600 43,500    
Translarna | Non-US            
New Accounting Pronouncements or Change in Accounting Principle [Line Items]            
Revenue     $ 79,200 $ 46,500