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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Collaboration and royalty revenue
Revenue	$ 148,735	$ 117,942
Collaboration and grant revenue
Collaboration and royalty revenue
Revenue	7	20,007
Royalty revenue
Collaboration and royalty revenue
Revenue	18,896	6,655
SMA License Agreement | Collaboration and grant revenue
Collaboration and royalty revenue
Revenue	0	20,000
SMA License Agreement | Royalty revenue
Collaboration and royalty revenue
Revenue	$ 18,900	6,700
SMA License Agreement | Sales Milestones
Collaboration and royalty revenue
Milestone payments received		$ 20,000

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