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Leases - Narrative (Details)
$ in Thousands
3 Months Ended 12 Months Ended
Jun. 19, 2020
USD ($)
room
Mar. 31, 2022
USD ($)
ft²
item
lease
Mar. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2021
USD ($)
Leases          
Number of operating leases | lease   3      
Number of new leases entered into during the period. | lease   1      
Operating lease, expense   $ 5,300 $ 5,400    
Finance lease liabilities- current   1,772     $ 3,000
Finance lease liabilities- noncurrent   18,675     $ 20,053
Aggregate rent, Initial term   128,071      
2022 (excludes the three months ended March 31, 2022)   10,154      
2023   13,298      
Finance Lease, Right-of-Use Asset   0      
Research and development   140,078 134,513    
MassBio          
Leases          
Finance lease cost   $ 400 $ 400    
Written notice required for early lease termination 24 months        
Number of dedicated rooms provided for gene therapy AADC program | room 4        
Guaranteed lease payment due at onset of the lease agreement $ 15,000        
Guaranteed lease payments due annually 3,000        
Present value of guaranteed lease payments $ 41,400        
Finance lease, term of contract 12 years 6 months        
Research and development       $ 41,400  
Minimum          
Leases          
Operating lease, term of contract   1 month 6 days      
Maximum          
Leases          
Operating lease, term of contract   13 years 3 months 18 days      
Renewal Term   10 years      
New Building | Minimum          
Leases          
Area of real estate property | ft²   75,000      
Hopewell Campus          
Leases          
Operating lease, term of contract   15 years      
Area of real estate property | ft²   220,500      
Renewal Term   10 years      
Number of renewable terms | item   2      
Aggregate rent, Initial term   $ 111,500      
Percent of market rate   95.00%      
Mountain View          
Leases          
2022 (excludes the three months ended March 31, 2022)   $ 900      
Thereafter   $ 0