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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Revenues:    
Revenue $ 148,735 $ 117,942
Operating expenses:    
Cost of product sales, excluding amortization of acquired intangible assets 10,135 9,104
Amortization of intangible assets 23,473 11,278
Research and development 140,078 134,513
Selling, general and administrative 73,271 61,095
Change in the fair value of deferred and contingent consideration (11,700) 100
Total operating expenses 235,257 216,090
Loss from operations (86,522) (98,148)
Interest expense, net (23,514) (19,159)
Other expense, net (11,855) (10,884)
Loss before income tax expense (121,891) (128,191)
Income tax expense (4,835) (451)
Net loss attributable to common stockholders $ (126,726) $ (128,642)
Weighted-average shares outstanding:    
Basic 71,215,105 70,188,602
Diluted 71,215,105 70,188,602
Net loss per share-basic and diluted (in dollars per share)    
Basic $ (1.78) $ (1.83)
Diluted $ (1.78) $ (1.83)
Net product revenue    
Revenues:    
Revenue $ 129,832 $ 91,280
Collaboration revenue    
Revenues:    
Revenue 7 20,007
Royalty revenue    
Revenues:    
Revenue $ 18,896 $ 6,655