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Fair value of financial instruments and marketable securities - Narrative (Details)
 1 Months Ended 3 Months Ended
Aug. 31, 2021
USD ($)
Feb. 28, 2021
USD ($)
fund
$ / shares
Jan. 31, 2020
USD ($)
$ / shares
May 31, 2019
USD ($)
$ / shares
Mar. 31, 2022
USD ($)
Mar. 31, 2021
USD ($)
Dec. 31, 2021
USD ($)
Apr. 29, 2020
USD ($)
Sep. 30, 2019
USD ($)
Aug. 31, 2015
USD ($)
Financial assets and liabilities measured at fair value on recurring basis                    
Write downs of available for sale debt securities         $ 0          
Realized gain (loss) from sale of marketable securities         (100,000) $ 700,000        
Increase in allowance for credit losses         0 0        
Purchase of equity investments           100,000        
Unrealized gain (loss) on ClearPoint Equity Investment         (1,049,000) 6,764,000        
Purchase of convertible note         39,035,000 141,985,000        
Unrealized gain (loss) on convertible note         (1,542,000) 7,858,000        
Purchase of marketable securities - equity investments           200,000,000        
Redemption of marketable securities- equity investments         2,423,000          
Transfers of assets measured between Level 1, Level 2, and Level 3         0   $ 0      
Operating Expenses         235,257,000 216,090,000        
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset         11,700,000 (100,000)        
3.00% Convertible senior notes due 2022 | Convertible debt                    
Financial assets and liabilities measured at fair value on recurring basis                    
Principal         150,000,000   150,000,000     $ 150,000,000.0
Interest rate ( as a percent )                   3.00%
Fair value of convertible notes         155,700,000   158,300,000      
1.50% Convertible senior notes due 2026 | Convertible debt                    
Financial assets and liabilities measured at fair value on recurring basis                    
Principal         $ 287,500,000   287,500,000   $ 287,500,000  
Interest rate ( as a percent )         1.50%       1.50%  
Fair value of convertible notes         $ 287,500,000   305,300,000      
Agilis                    
Financial assets and liabilities measured at fair value on recurring basis                    
Development milestone payments which the entity is obligated to pay         $ 40,000,000.0     $ 40,000,000.0    
Agilis | Minimum                    
Financial assets and liabilities measured at fair value on recurring basis                    
Product sales (as a percent)         2.00%          
Agilis | Maximum                    
Financial assets and liabilities measured at fair value on recurring basis                    
Product sales (as a percent)         6.00%          
Development milestone payments which the entity is obligated to pay         $ 60,000,000.0          
Priority review voucher amount         535,000,000.0          
Net sales amount         150,000,000.0          
Recurring basis                    
Financial assets and liabilities measured at fair value on recurring basis                    
Fair value of convertible debt         19,429,000   20,971,000      
ClearPoint equity investment                    
Financial assets and liabilities measured at fair value on recurring basis                    
Purchase of equity investments   $ 100,000   $ 4,000,000.0            
Share price (in USD per share) | $ / shares   $ 23.50   $ 3.10            
Unrealized gain (loss) on ClearPoint Equity Investment         (1,000,000.0) 6,800,000        
Marketable securities - equity investments         13,500,000   14,500,000      
ClearPoint convertible debt                    
Financial assets and liabilities measured at fair value on recurring basis                    
Purchase of convertible debt investment     $ 10,000,000.0              
Conversion price - convertible note | $ / shares     $ 6.00              
Unrealized gain (loss) on convertible note         (1,500,000) 7,900,000        
Fair value of convertible debt         19,400,000   $ 21,000,000.0      
Mutual Funds                    
Financial assets and liabilities measured at fair value on recurring basis                    
Purchase of marketable securities - equity investments   $ 200,000,000.0                
Number of mutual funds invested in | fund   2                
Redemption of marketable securities- equity investments         2,400,000 0.0        
Unrealized loss on marketable securities - equity investments         6,500,000 300,000        
Unrealized foreign currency transaction losses, net         $ 700,000 $ (0.0)        
Mutual Fund, Purchase One                    
Financial assets and liabilities measured at fair value on recurring basis                    
Purchase of marketable securities - equity investments $ 5,400,000                  
Mutual Fund, Purchase Two                    
Financial assets and liabilities measured at fair value on recurring basis                    
Purchase of marketable securities - equity investments $ 4,600,000