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Fair value of financial instruments and investments - Marketable Securities, Unrealized Gains (Losses) (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Debt Securities, Available-for-sale [Line Items]
Amortized Cost	$ 248,335		$ 377,287
Gross Unrealized, Gain	30		107
Gross Unrealized, Loss	(3,545)		(709)
Fair Value	244,820		376,685
Write downs of available for sale debt securities	0
Increase in allowance for credit losses	0	$ 0
Realized gain (loss) from sale of marketable securities	(100)	$ 700
Commercial paper
Debt Securities, Available-for-sale [Line Items]
Amortized Cost	27,292		75,275
Gross Unrealized, Gain	0		5
Gross Unrealized, Loss	(11)		(1)
Fair Value	27,281		75,279
Corporate debt securities
Debt Securities, Available-for-sale [Line Items]
Amortized Cost	187,121		268,246
Gross Unrealized, Gain	18		81
Gross Unrealized, Loss	(3,139)		(644)
Fair Value	184,000		267,683
Asset-backed securities
Debt Securities, Available-for-sale [Line Items]
Amortized Cost	10,202		15,287
Gross Unrealized, Gain	7		16
Gross Unrealized, Loss	(37)		(5)
Fair Value	10,172		15,298
Government obligations
Debt Securities, Available-for-sale [Line Items]
Amortized Cost	23,720		18,479
Gross Unrealized, Gain	5		5
Gross Unrealized, Loss	(358)		(59)
Fair Value	$ 23,367		$ 18,425

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Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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