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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Employee compensation, benefits, and related accruals	$ 29,485	$ 55,733
Income tax payable	4,549	1,287
Consulting and contracted research	28,391	26,434
Professional fees	5,013	3,547
Sales allowance	63,109	61,662
Sales rebates	57,680	68,770
Royalties	30,670	35,679
Accounts payable	18,365	23,033
Other	9,259	12,639
Accounts payable and accrued expenses	$ 246,521	$ 288,784

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