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Stock award plan - Stock Option Activity (Details) - Stock option
$ / shares in Units, $ in Thousands
 3 Months Ended
Mar. 31, 2022
USD ($)
$ / shares
shares
Number of options  
Outstanding at the beginning of the period (in shares) | shares 10,772,582
Granted (in shares) | shares 1,275,830
Exercised (in shares) | shares (97,188)
Forfeited/Cancelled (in shares) | shares (199,511)
Outstanding at the end of the period (in shares) | shares 11,751,713
Vested or Expected to vest at the end of the period (in shares) | shares 4,497,327
Exercisable at the end of the period (in shares) | shares 6,763,376
Weighted- average exercise price  
Outstanding at the beginning of the period (in dollars per share) | $ / shares $ 43.66
Granted (in dollars per share) | $ / shares 38.10
Exercised (in dollars per share) | $ / shares 25.15
Forfeited/Cancelled (in dollars per share) | $ / shares 49.92
Outstanding at the end of the period (in dollars per share) | $ / shares 43.11
Vested or Expected to vest at the end of the period (in dollars per share) | $ / shares 48.04
Exercisable at the end of the period (in dollars per share) | $ / shares $ 39.44
Weighted- average remaining contractual term  
Outstanding at the end of the period 6 years 11 months 19 days
Vested or Expected to vest at the end of the period 8 years 6 months 14 days
Exercisable at the end of the period 5 years 9 months 14 days
Aggregate intrinsic value (in thousands)  
Outstanding at the end of the period (in dollars) | $ $ 38,075
Vested or Expected to vest at the end of the period (in dollars) | $ 2,127
Exercisable at the end of the period (in dollars) | $ $ 35,859