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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - Commitments - USD ($) $ in Thousands | 6 Months Ended
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Jun. 30, 2022 | Jun. 30, 2021
Development and Regulatory Milestones |  |
Changes in the fair value of warrant liability and SARs liability |  |
Beginning Balance | $ 139,300 | $ 139,200
Additions | 0 | 0
Change in fair value | (10,600) | 400
Reclass to accounts payable and accrued expenses | (50,000) |
Rights Exchange settlement | 0 | 0
Ending Balance | 78,700 | 139,600
Net Sales Milestones and Royalties |  |
Changes in the fair value of warrant liability and SARs liability |  |
Beginning Balance | 100,600 | 101,200
Additions | 0 | 0
Change in fair value | (16,300) | 400
Reclass to accounts payable and accrued expenses | 0 |
Rights Exchange settlement | 0 | 0
Ending Balance | $ 84,300 | $ 101,600

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- Definition A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period. + References No definition available. + Details
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- Definition Amount of transfers of financial instrument classified as a liability out of level 3 of the fair value hierarchy. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(3) -URI http://asc.fasb.org/extlink&oid=123874694&loc=d3e19207-110258 + Details
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- Definition Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=123874694&loc=d3e19207-110258 + Details
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- Definition Amount of issuances of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=123874694&loc=d3e19207-110258 + Details
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