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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Collaboration and royalty revenue |  |  |  |
Revenue | $ 165,526 | $ 116,676 | $ 314,262 | $ 234,620
Collaboration and grant revenue |  |  |  |
Collaboration and royalty revenue |  |  |  |
Revenue |  |  | 7 | 20,007
Royalty revenue |  |  |  |
Collaboration and royalty revenue |  |  |  |
Revenue | 21,825 | 13,563 | 40,721 | 20,220
SMA License Agreement | Collaboration and grant revenue |  |  |  |
Collaboration and royalty revenue |  |  |  |
Revenue | 0 | 0 | 0 | 20,000
SMA License Agreement | Royalty revenue |  |  |  |
Collaboration and royalty revenue |  |  |  |
Revenue | $ 21,800 | 13,600 | $ 40,700 | 20,200
SMA License Agreement | Sales Milestones |  |  |  |
Collaboration and royalty revenue |  |  |  |
Milestone payments received |  | $ 20,000 |  | $ 20,000

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