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Stock award plan - (Tables)

6 Months Ended

Jun. 30, 2022

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​		​		​	​		Weighted-			​	​
​	​	​	​	Weighted-		​	average	​	​	Aggregate
​	​	​	​	average		​	remaining	​	​	intrinsic
​	​	Number of	​	exercise		​	contractual	​	​	value(in
​	​	options	​	price		​	term	​	​	thousands)
​	​	​	​	​	​	​	​		​	​	​
Outstanding at December 31, 2021		10,772,582	​	$	43.66				​	​
Granted		1,471,290	​	​	37.86				​	​
Exercised		(125,020)	​	​	25.59				​	​
Forfeited/Cancelled		(302,900)	​	​	49.52				​	​
Outstanding at June 30, 2022		11,815,952	​	$	42.98		6.79	years	​	$	52,784
Vested or Expected to vest at June 30, 2022		4,180,409	​	$	47.70		8.42	years	​	$	6,220
Exercisable at June 30, 2022		7,208,199	​	$	39.96		5.72	years	​	$	45,995

​

Schedule of assumptions used to estimate fair values of grants made on the date of grant

​

​	​	​
​		Six months ended
​		June 30, 2022
Risk-free interest rate		1.55% - 3.07%
Expected volatility		55.33% - 73.56%
Expected term		5.5 years

Summary of information on the Company's restricted stock

​

​	​	​	​	​	​
​	​	Restricted Stock Awards and Units
​	​	​	​	Weighted
​	​	​	​	Average
​	​	​	​	Grant
​	​	Number of	​	Date
​		Shares		Fair Value
Unvested at December 31, 2021	​	1,519,831	​	$	55.43
Granted		1,580,362	​	​	38.03
Vested		(476,223)	​	​	50.44
Forfeited		(109,143)	​	​	47.85
Unvested at June 30, 2022		2,514,827	​	$	45.74

Schedule of share-based compensation expense recorded in the statement of operations

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Three Months Ended June 30,

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Six Months Ended June 30,

​

​

2022

2021

2022

2021

​

Research and development

​

$

13,798

​

$

13,443

​

$

26,832

​

$

27,168

​

Selling, general and administrative

​

13,932

​

12,256

​

27,487

​

24,238

​

Total

​

$

27,730

​

$

25,699

​

$

54,319

​

$

51,406

​

​

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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