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Debt - (Tables)

6 Months Ended

Jun. 30, 2022

Debt Instrument, Redemption [Line Items]

Summary of liability for sale of future royalties


		Six Months Ended June 30,
Liability for sale of future royalties- (current and noncurrent)		2022
Beginning balance as of December 31, 2021		$	733,985
Less: Non-cash royalty revenue payable to RPI			(17,482)
Plus: Non-cash interest expense recognized			37,825
Ending balance		$	754,328
Effective interest rate as of June 30, 2022			10.1	%

1.50% Convertible senior notes due 2026

Debt Instrument, Redemption [Line Items]

Summary of convertible notes



Liability component		June 30, 2022			December 31, 2021
Principal		$	287,500		$	287,500
Less: Debt issuance costs			(5,040)			(5,606)
Net carrying amount		$	282,460		$	281,894

Summary of interest expense recognized related to the Convertible Notes



		Three Months Ended June 30,						Six Months Ended June 30,
		2022			2021			2022			2021
Contractual interest expense		$	1,066		$	1,066		$	2,135		$	2,135
Amortization of debt issuance costs			284			279			567			556
Total		$	1,350		$	1,345		$	2,702		$	2,691
Effective interest rate of the liability component			1.9	%		1.9	%		1.9	%		1.9	%

3.00% Convertible senior notes due 2022

Debt Instrument, Redemption [Line Items]

Summary of convertible notes




Liability component		June 30, 2022			December 31, 2021
Principal		$	150,000		$	150,000
Less: Debt issuance costs			(92)			(460)
Net carrying amount		$	149,908		$	149,540

Summary of interest expense recognized related to the Convertible Notes



		Three Months Ended June 30,						Six Months Ended June 30,
		2022			2021			2022			2021
Contractual interest expense		$	1,131		$	1,131		$	2,241		$	2,241
Amortization of debt issuance costs			186			180			368			355
Total		$	1,317		$	1,311		$	2,609		$	2,596
Effective interest rate of the liability component			3.5	%		3.5	%		3.5	%		3.5	%