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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Jul. 17, 2020
USD ($)
Dec. 22, 2017
May 31, 2022
USD ($)
Jun. 30, 2022
USD ($)
Jun. 30, 2021
USD ($)
Jun. 30, 2022
USD ($)
segment
Jun. 30, 2021
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Number of operating segments | segment           1        
Allowance for credit loss       $ 0 $ 0 $ 0 $ 0      
Increase in allowance for credit losses       0 0 0 0      
Allowance for doubtful accounts receivable       100   100     $ 100  
Revenue       165,526 116,676 314,262 234,620      
Deferred payroll taxes provided for under CARES Act           1,300        
Cash consideration received from Royalty Purchase Agreement $ 650,000                  
Income taxes                    
Federal income tax statutory rate   21.00%                
Federal income tax provision - IRC Section 174 R&D Expenses           1,600        
State income tax provision - IRC Section 174 R&D Expenses       5,400            
Agilis                    
Income taxes                    
Deferred tax liability                   $ 122,000
Deposits and other assets                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Bank guarantee       500   500        
Hopewell Campus                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Period after which letter of credit may be reduced if lease is not in default               5 years    
Hopewell Campus | Minimum                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Term for letter of credit (in years)               5 years    
Hopewell Campus | Deposits and other assets                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Letters of credit               $ 7,500    
Hopewell Campus | Fifth Anniversary                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Letters of credit               $ 3,800    
Warren Premises                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Period after which letter of credit may be reduced if lease is not in default     5 years              
Warren Premises | Deposits and other assets                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Letters of credit     $ 8,100              
Warren Premises | Fifth Anniversary                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Letters of credit     $ 4,100              
Net product revenue                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Revenue       143,701 103,113 273,534 194,393      
Net product revenue | Non-US                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Revenue       86,900 54,000 168,100 101,700      
Emflaza | United States                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Revenue       56,800 49,100 105,400 92,700      
Translarna | Non-US                    
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                    
Revenue       $ 77,000 $ 52,600 $ 156,200 $ 99,100