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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Collaboration and royalty revenue
Revenue	$ 165,526	$ 116,676	$ 314,262	$ 234,620
Collaboration and grant revenue
Collaboration and royalty revenue
Revenue			7	20,007
Royalty revenue
Collaboration and royalty revenue
Revenue	21,825	13,563	40,721	20,220
SMA License Agreement | Collaboration and grant revenue
Collaboration and royalty revenue
Revenue	0	0	0	20,000
SMA License Agreement | Royalty revenue
Collaboration and royalty revenue
Revenue	$ 21,800	13,600	$ 40,700	20,200
SMA License Agreement | Sales Milestones
Collaboration and royalty revenue
Milestone payments received		$ 20,000		$ 20,000

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