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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Revenues:        
Revenue $ 165,526 $ 116,676 $ 314,262 $ 234,620
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible assets 9,639 7,358 19,774 16,462
Amortization of intangible assets 26,294 12,751 49,767 24,028
Research and development 157,263 125,482 297,341 259,995
Selling, general and administrative 79,892 68,878 153,162 129,973
Change in the fair value of deferred and contingent consideration (15,200) 700 (26,900) 800
Total operating expenses 257,888 215,169 493,144 431,258
Loss from operations (92,362) (98,493) (178,882) (196,638)
Interest expense, net (21,976) (22,559) (45,490) (41,718)
Other (expense) income, net (34,357) 3,170 (46,214) (7,716)
Loss before income tax expense (148,695) (117,882) (270,586) (246,072)
Income tax expense (3,392) (488) (8,227) (940)
Net loss attributable to common stockholders $ (152,087) $ (118,370) $ (278,813) $ (247,012)
Weighted-average shares outstanding:        
Basic 71,372,940 70,414,632 71,294,458 70,302,241
Diluted 71,372,940 70,414,632 71,294,458 70,302,241
Net loss per share-basic and diluted (in dollars per share)        
Basic $ (2.13) $ (1.68) $ (3.91) $ (3.51)
Diluted $ (2.62) $ (1.68) $ (4.40) $ (3.51)
Net product revenue        
Revenues:        
Revenue $ 143,701 $ 103,113 $ 273,534 $ 194,393
Collaboration revenue        
Revenues:        
Revenue     7 20,007
Royalty revenue        
Revenues:        
Revenue $ 21,825 $ 13,563 $ 40,721 $ 20,220