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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - Commitments - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Development and Regulatory Milestones
Changes in the fair value of warrant liability and SARs liability
Beginning Balance	$ 139,300	$ 139,200
Additions	0	0
Change in fair value	(10,600)	400
Reclass to accounts payable and accrued expenses	(50,000)
Rights Exchange settlement	0	0
Ending Balance	78,700	139,600
Net Sales Milestones and Royalties
Changes in the fair value of warrant liability and SARs liability
Beginning Balance	100,600	101,200
Additions	0	0
Change in fair value	(16,300)	400
Reclass to accounts payable and accrued expenses	0
Rights Exchange settlement	0	0
Ending Balance	$ 84,300	$ 101,600

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- Definition

Amount of transfers of financial instrument classified as a liability out of level 3 of the fair value hierarchy.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
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Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3).

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Amount of issuances of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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