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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Employee compensation, benefits, and related accruals	$ 35,834	$ 55,733
Income tax payable	7,582	1,287
Consulting and contracted research	30,866	26,434
Professional fees	5,196	3,547
Sales allowance	64,335	61,662
Sales rebates	71,776	68,770
Royalties	34,230	35,679
Accounts payable	22,881	23,033
Milestone payable	50,000
Other	8,218	12,639
Accounts payable and accrued expenses	$ 330,918	$ 288,784

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