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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Jun. 08, 2022
Dec. 31, 2020
Jun. 30, 2016
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Apr. 30, 2022
May 31, 2021
Jan. 31, 2020
Stock option plan                    
Share-based compensation expense       $ 27,730 $ 25,699 $ 54,319 $ 51,406      
Unrecognized compensation cost       227,400   $ 227,400        
Weighted average remaining service period for recognition of unrecognized compensation cost           2 years 5 months 19 days        
Stock option                    
Stock option plan                    
Granted (in shares)           1,471,290        
Expected dividend yield (as a percent)           0.00%        
Weighted average grant date fair value (in dollars per share)           $ 23.60        
Restricted stock units                    
Stock option plan                    
Granted (in shares)           1,580,362        
Employee Stock Purchase Plan                    
Stock option plan                    
Number of shares authorized (in shares)         2,000,000   2,000,000   1,000,000  
Award requisite service period     6 months              
Purchase price of common stock, percent     85.00%              
Employee stock purchase plan, voting percentage limit     5.00%              
Share-based compensation expense       $ 500   $ 1,000        
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock                    
Stock option plan                    
Number of shares available for issuance       0   0        
Amended 2013 LTIP                    
Stock option plan                    
Number of shares available for issuance       9,306,210   9,306,210        
Number of additional shares authorized (in shares) 8,475,000                  
Amended 2013 LTIP | Maximum                    
Stock option plan                    
Number of shares authorized (in shares) 16,724,212                  
2020 Inducement Stock Incentive Plan                    
Stock option plan                    
Vesting period           4 years        
2020 Inducement Stock Incentive Plan | Maximum                    
Stock option plan                    
Expiration period           10 years        
2020 Inducement Stock Incentive Plan | Common stock                    
Stock option plan                    
Number of shares available for issuance       46,233   46,233        
Number of additional shares authorized (in shares)   1,000,000                
2020 Inducement Stock Incentive Plan | Common stock | Maximum                    
Stock option plan                    
Number of shares authorized (in shares)               1,300,000   1,000,000
2020 Inducement Stock Incentive Plan | Stock option                    
Stock option plan                    
Stockholder's specified ownership percentage       10.00%   10.00%        
Inducement grants for non-statutory stock options (in shares)           104,385        
2020 Inducement Stock Incentive Plan | Stock option | Minimum                    
Stock option plan                    
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date       100.00%   100.00%        
2020 Inducement Stock Incentive Plan | Stock option | Maximum                    
Stock option plan                    
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date       110.00%   110.00%        
2020 Inducement Stock Incentive Plan | Restricted stock units                    
Stock option plan                    
Granted (in shares)           43,800