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Stock award plan - Stock Option Activity (Details) - Stock option - USD ($)
$ / shares in Units, $ in Thousands
6 Months Ended
Jun. 30, 2022
Number of options  
Outstanding at the beginning of the period (in shares) 10,772,582
Granted (in shares) 1,471,290
Exercised (in shares) (125,020)
Forfeited/Cancelled (in shares) (302,900)
Outstanding at the end of the period (in shares) 11,815,952
Vested or Expected to vest at the end of the period (in shares) 4,180,409
Exercisable at the end of the period (in shares) 7,208,199
Weighted- average exercise price  
Outstanding at the beginning of the period (in dollars per share) $ 43.66
Granted (in dollars per share) 37.86
Exercised (in dollars per share) 25.59
Forfeited/Cancelled (in dollars per share) 49.52
Outstanding at the end of the period (in dollars per share) 42.98
Vested or Expected to vest at the end of the period (in dollars per share) 47.70
Exercisable at the end of the period (in dollars per share) $ 39.96
Weighted- average remaining contractual term  
Outstanding at the end of the period 6 years 9 months 14 days
Vested or Expected to vest at the end of the period 8 years 5 months 1 day
Exercisable at the end of the period 5 years 8 months 19 days
Aggregate intrinsic value (in thousands)  
Outstanding at the end of the period (in dollars) $ 52,784
Vested or Expected to vest at the end of the period (in dollars) 6,220
Exercisable at the end of the period (in dollars) $ 45,995