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Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Stock option plan
Share-based compensation expense	$ 27,730	$ 25,699	$ 54,319	$ 51,406
Unrecognized compensation cost	227,400		$ 227,400
Weighted average remaining service period for recognition of unrecognized compensation cost			2 years 5 months 19 days
Research and development
Stock option plan
Share-based compensation expense	13,798	13,443	$ 26,832	27,168
Selling, general and administrative
Stock option plan
Share-based compensation expense	$ 13,932	$ 12,256	$ 27,487	$ 24,238

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
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-SubTopic 10
-Section S99
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-URI http://asc.fasb.org/extlink&oid=122041274&loc=d3e301413-122809

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- Definition

Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
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X

- Definition

Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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