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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands		1 Months Ended			3 Months Ended			6 Months Ended		46 Months Ended
	Apr. 20, 2017	Aug. 31, 2021	Dec. 31, 2019	May 31, 2019	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2018	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Dec. 31, 2021	Aug. 23, 2018
Finite-Lived Intangible Assets
Milestone payable					$ 50,000			$ 50,000		$ 50,000
Amortization of intangible assets					26,294	$ 12,751		49,767	$ 24,028
Total allocation of IPR&D assets								576,500
Change in indefinite-lived intangibles										0
Accrued royalties					34,230			34,230		34,230	$ 35,679
Goodwill					82,341			82,341		82,341	$ 82,341
Changes in goodwill										0
Tegsedi
Finite-Lived Intangible Assets
Royalty payments					1,600	0		2,000	0
Accrued royalties					2,100			$ 2,100		2,100
Weighted Average
Finite-Lived Intangible Assets
Remaining amortization period								2 years
Akcea
Finite-Lived Intangible Assets
Milestone payments		$ 4,000
Marathon
Finite-Lived Intangible Assets
Milestone payments received					50,000			$ 50,000		50,000
Agilis
Finite-Lived Intangible Assets
Goodwill												$ 82,300
Goodwill adjustment							$ 18,000
Agilis Merger Agreement | Akcea
Finite-Lived Intangible Assets
Milestone payments			$ 4,000	$ 6,000
Useful life			10 years
Emflaza asset acquisition
Finite-Lived Intangible Assets
Finite-lived intangibles	$ 148,400
Milestone obligation payments recorded					21,700	$ 17,100		83,800	$ 26,000
Useful life	7 years
Emflaza asset acquisition | Accounts payable and accrued expenses
Finite-Lived Intangible Assets
Milestone payable					$ 24,500			$ 24,500		$ 24,500

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