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v3.22.2.2

Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Sep. 30, 2022 | Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Aug. 31, 2021 | Mar. 31, 2021
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | $ 217,127 | $ 138,743 | $ 531,389 | $ 373,364 |  |
Collaboration and grant revenue |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | 50,017 | 10,011 | 50,024 | 30,018 |  |
Royalty revenue |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | 32,924 | 13,127 | 73,645 | 33,348 |  |
SMA License Agreement | Collaboration and grant revenue |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | 50,000 | 10,000 | 50,000 | 30,000 |  |
SMA License Agreement | Royalty revenue |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Revenue |  | $ 32,900 | 13,100 | $ 73,600 | 33,300 |  |
SMA License Agreement | Sales Milestones |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Milestone payments received |  |  | $ 20,000 |  | $ 20,000 | $ 10,000 | $ 20,000
Net sales milestone threshold achieved | $ 750,000 |  |  |  |  |  |
SMA License Agreement | Sales Milestones | Prepaids and other current assets |  |  |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |  |  |
Milestone payments due | $ 50,000 |  |  |  |  |  |

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