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Leases - Narrative (Details) $ in Thousands |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | ---
Jul. 01, 2020 USD ($) ft² item | Jun. 19, 2020 USD ($) room | May 31, 2022 USD ($) ft² period building | Sep. 30, 2022 USD ($) lease | Sep. 30, 2021 USD ($) | Sep. 30, 2022 USD ($) lease | Sep. 30, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2021 USD ($)
Leases |  |  |  |  |  |  |  |  |
Number of operating leases | lease |  |  |  | 2 |  | 2 |  |  |
Operating lease, expense |  |  |  | $ 6,800 | $ 5,300 | $ 18,000 | $ 15,900 |  |
Finance lease liabilities- current |  |  |  | 2,583 |  | 2,583 |  |  | $ 3,000
Finance lease liabilities- noncurrent |  |  |  | 18,675 |  | 18,675 |  |  | 20,053
Aggregate rent, Initial term |  |  |  | 271,188 |  | 271,188 |  |  |
Operating lease ROU assets |  |  |  | 104,901 |  | 104,901 |  |  | $ 77,421
Operating Lease, Liability |  |  |  | 111,019 |  | 111,019 |  |  |
Finance Lease, Right-of-Use Asset |  |  |  | 0 |  | 0 |  |  |
Research and development |  |  |  | 165,462 | 130,845 | 462,802 | 390,840 |  |
MassBio |  |  |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |  |  |
Lessee, Finance Lease, Existence of Option to Terminate [true false] |  | true |  |  |  |  |  |  |
Finance lease cost |  |  |  | $ 400 | $ 400 | $ 1,200 | $ 1,300 |  |
Written notice required for early lease termination |  | 24 months |  |  |  |  |  |  |
Number of dedicated rooms provided for gene therapy AADC program | room |  | 4 |  |  |  |  |  |  |
Guaranteed lease payment due at onset of the lease agreement |  | $ 15,000 |  |  |  |  |  |  |
Guaranteed lease payments due annually |  | 3,000 |  |  |  |  |  |  |
Present value of guaranteed lease payments |  | $ 41,400 |  |  |  |  |  |  |
Finance lease, term of contract |  | 12 years 6 months |  |  |  |  |  |  |
Research and development |  |  |  |  |  |  |  | $ 41,400 |
Minimum |  |  |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |  |  |
Operating lease, term of contract |  |  |  | 1 month 6 days |  | 1 month 6 days |  |  |
Maximum |  |  |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |  |  |
Operating lease, term of contract |  |  |  | 16 years 8 months 12 days |  | 16 years 8 months 12 days |  |  |
Renewal term |  |  |  | 15 years |  | 15 years |  |  |
Hopewell Campus |  |  |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |  |  |
Operating lease, term of contract | 15 years |  |  |  |  |  |  |  |
Area of real estate property | ft² | 220,500 |  |  |  |  |  |  |  |
Renewal term | 10 years |  |  |  |  |  |  |  |
Number of renewable terms | item | 2 |  |  |  |  |  |  |  |
Lessee, Operating Lease, Existence of Option to Extend [true false] | true |  |  |  |  |  |  |  |
Aggregate rent, Initial term | $ 111,500 |  |  |  |  |  |  |  |
Percent of market rate | 95.00% |  |  |  |  |  |  |  |
Warren Premises |  |  |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |  |  |
Operating lease, term of contract |  |  | 17 years |  |  |  |  |  |
Number of buildings leased | building |  |  | 2 |  |  |  |  |  |
Area of real estate property | ft² |  |  | 360,000 |  |  |  |  |  |
Renewal term |  |  | 5 years |  |  |  |  |  |
Number of renewable terms | period |  |  | 3 |  |  |  |  |  |
Lessee, Operating Lease, Existence of Option to Extend [true false] |  |  | true |  |  |  |  |  |
Aggregate rent, Initial term |  |  | $ 163,000 |  |  |  |  |  |
Base rent abatement period |  |  | 3 years |  |  |  |  |  |
Base rent abatement |  |  | $ 18,600 |  |  |  |  |  |
Aggregate rent net of base rate abatement, initial term |  |  | 144,400 |  |  |  |  |  |
Allowance for lease improvements |  |  | 36,200 |  |  |  |  |  |
Commitment to fund construction account |  |  | 3,600 |  |  |  |  |  |
Payment due from lessor at issuance of temporary certificate of occupancy |  |  | 5,000 |  |  |  |  |  |
Operating lease ROU assets |  |  | 28,900 |  |  |  |  |  |
Operating Lease, Liability |  |  | $ 28,900 |  |  |  |  |  |

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