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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 49 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | ---
Apr. 20, 2017 | Jul. 31, 2022 | Aug. 31, 2021 | Dec. 31, 2019 | May 31, 2019 | Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Dec. 31, 2021 | Aug. 23, 2018
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payable |  |  |  |  |  | $ 50,000 |  | $ 50,000 |  | $ 50,000 |  |
Amortization of intangible assets |  |  |  |  |  | 31,023 | $ 14,383 | 80,790 | $ 38,411 |  |  |
Accrued royalties |  |  |  |  |  | 41,897 |  | 41,897 |  | 41,897 | $ 35,679 |
Goodwill |  |  |  |  |  | 82,341 |  | 82,341 |  | 82,341 | $ 82,341 |
Changes in goodwill |  |  |  |  |  |  |  |  |  | 0 |  |
Tegsedi |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments |  |  |  |  |  | 500 | 0 | $ 2,500 | 0 |  |  |
Weighted Average |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Remaining amortization period |  |  |  |  |  |  |  | 5 years 1 month 6 days |  |  |  |
Accounts payable and accrued expenses | Tegsedi |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Accrued royalties |  |  |  |  |  | 500 |  | $ 500 |  | 500 |  |
Akcea |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  |  | $ 4,000 |  |  |  |  |  |  |  |  |
Marathon |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments received |  |  |  |  |  | 50,000 |  | 50,000 |  | 50,000 |  |
Agilis |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangibles |  | $ 89,500 |  |  |  |  |  |  |  |  |  |
Useful life |  | 12 years |  |  |  |  |  |  |  |  |  |
Indefinite-lived intangible assets acquired |  |  |  |  |  |  |  |  |  |  |  | $ 576,500
Reclassification out of indefinite-lived intangible assets on successful completion of R&D efforts |  | $ 89,500 |  |  |  |  |  |  |  |  |  |
Indefinite-lived intangible assets |  |  |  |  |  | 487,000 |  | 487,000 |  | 487,000 |  |
Goodwill |  |  |  |  |  |  |  |  |  |  |  | $ 82,300
Agilis | Accounts payable and accrued expenses |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payable |  |  |  |  |  | 50,000 |  | 50,000 |  | 50,000 |  |
Agilis Merger Agreement | Akcea |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  |  |  | $ 4,000 | $ 6,000 |  |  |  |  |  |  |
Useful life |  |  |  | 10 years |  |  |  |  |  |  |  |
Agilis Merger Agreement | Marathon |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone obligation payments made |  |  |  |  |  |  |  | 50,000 |  |  |  |
Emflaza asset acquisition |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangibles | $ 148,400 |  |  |  |  |  |  |  |  |  |  |
Milestone obligation payments recorded |  |  |  |  |  | 21,300 | $ 16,800 | 105,100 | $ 42,800 |  |  |
Useful life | 7 years |  |  |  |  |  |  |  |  |  |  |
Emflaza asset acquisition | Accounts payable and accrued expenses |  |  |  |  |  |  |  |  |  |  |  |
Finite-Lived Intangible Assets |  |  |  |  |  |  |  |  |  |  |  |
Milestone payable |  |  |  |  |  | $ 27,400 |  | $ 27,400 |  | $ 27,400 |  |

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