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Fair value of financial instruments and marketable securities - Hierarchy (Details) - USD ($) $ in Thousands | Sep. 30, 2022 | Dec. 31, 2021
--- | --- | ---
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - available for sale | $ 71,000 | $ 376,685
Contingent consideration payable | 157,700 | 239,900
Recurring basis |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
ClearPoint Equity Investments | 13,412 | 14,525
ClearPoint convertible debt security | 18,579 | 20,971
Recurring basis | Quoted prices in active markets for identical assets (Level 1) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
ClearPoint Equity Investments | 13,412 | 14,525
Recurring basis | Significant other observable inputs (Level 2) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
ClearPoint convertible debt security | 18,579 | 20,971
Recurring basis | Development and Regulatory Milestones |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 78,500 | 139,300
Recurring basis | Development and Regulatory Milestones | Significant unobservable inputs (Level 3) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 78,500 | 139,300
Recurring basis | Net Sales Milestones and Royalties |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 79,200 | 100,600
Recurring basis | Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 79,200 | 100,600
Recurring basis | Marketable securities |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - available for sale | 71,000 | 376,685
Marketable securities - equity investments | 113,008 | 206,973
Recurring basis | Marketable securities | Quoted prices in active markets for identical assets (Level 1) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - equity investments | 113,008 | 206,973
Recurring basis | Marketable securities | Significant other observable inputs (Level 2) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - available for sale | $ 71,000 | $ 376,685

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- Definition Amount of investment in convertible debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References No definition available. + Details
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