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v3.22.2.2

Consolidated Statements of Cash Flows $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2022 USD ($) | Sep. 30, 2021 USD ($)
Cash flows from operating activities |  |
Net loss | $ (388,128) | $ (380,636)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 89,971 | 45,323
Non-cash operating lease expense | 7,505 | 5,516
Non-cash royalty revenue related to sale of future royalties | (31,617) | (14,317)
Non-cash interest expense on liability related to sale of future royalties | 55,778 | 57,755
Change in valuation of deferred and contingent consideration | (32,200) | 11,600
Unrealized loss (gain) on ClearPoint Equity Investments | 1,113 | (2,376)
Unrealized loss (gain) on ClearPoint convertible debt security | 2,392 | (2,054)
Unrealized loss (gain) on marketable securities - equity investments | 11,319 | (1,350)
Loss on disposal of asset | 81 |
Amortization of premiums on investments, net | 1,792 | 4,052
Amortization of debt issuance costs | 1,316 | 1,377
Share-based compensation expense | 82,989 | 77,277
Unrealized foreign currency transaction losses, net | 71,246 | 33,280
Changes in operating assets and liabilities: |  |
Inventory, net | (768) | 2,476
Prepaid expenses and other current assets | (35,615) | 8,161
Trade and royalty receivables, net | (24,773) | (28,625)
Deposits and other assets | (3,752) | (444)
Accounts payable and accrued expenses | 1,568 | 8,888
Other liabilities | (908) | (4,340)
Deferred revenue |  | (4,055)
Net cash used in operating activities | (190,691) | (182,492)
Cash flows from investing activities |  |
Purchases of fixed assets | (23,394) | (19,487)
Purchases of marketable securities - available for sale | (40,429) | (276,376)
Purchases of marketable securities - equity investments | (22,787) | (205,382)
Sale and redemption of marketable securities- available for sale | 341,990 | 693,319
Sale and redemption of marketable securities - equity investments | 104,431 | 740
Acquisition of product rights and licenses | (102,069) | (41,806)
Purchase of equity investment in ClearPoint |  | (100)
Net cash provided by investing activities | 257,742 | 150,908
Cash flows from financing activities |  |
Proceeds from exercise of options | 13,203 | 16,120
Repayment of Convertible Notes | (150,000) |
Proceeds from employee stock purchase plan | 3,107 | 2,627
Payment of finance lease principal | (1,276) | (2,224)
Net cash provided by financing activities | (134,966) | 16,523
Effect of exchange rate changes on cash | (8,792) | (3,933)
Net decrease in cash and cash equivalents | (76,707) | (18,994)
Cash and cash equivalents, and restricted cash beginning of period | 197,218 | 216,312
Cash and cash equivalents, and restricted cash end of period | 120,511 | 197,318
Supplemental disclosure of cash information |  |
Cash paid for interest | 12,679 | 9,589
Cash paid for income taxes | 4,029 | 5,527
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized loss on marketable securities, net of tax | (2,333) | (1,505)
Right-of-use assets obtained in exchange for operating lease obligations | 35,294 |
Acquisition of product rights and licenses | 27,828 | $ 19,154
Milestone payable | $ 50,000 |

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