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Income taxes - Narrative (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2018
Operating loss carryforwards |  |  |  |
Taxable income before consideration of NOL | $ 61,600 |  |  |
State income tax provision | 4,224 | $ 3,844 | $ 24,984 |
Deferred tax valuation allowance | 672,172 | 525,570 |  |
Valuation allowance, deferred tax asset, increase (decrease) | 146,600 | 146,000 |  |
Deferred tax liability on indefinite-lived intangibles acquired | 102,834 | 137,110 |  |
Orphan Drug Credit carryover | 145,800 |  |  |
Net operating loss carryforwards utilized | $ 49,300 | $ 0 | $ 364,100 |
Federal income tax provision at statutory rate | 21.00% | 21.00% | 21.00% |
Uncertain tax position | $ 0 |  |  |
Increase in current taxable income resulting from the elimination of current deduction of qualifying R&D costs under Section 174. | 450,100 |  |  |
Undistributed earnings from non-US subsidiaries | 65,100 |  |  |
Undistributed earnings from non-US subsidiaries, tax | 0 |  |  |
Unrecognized tax benefits | 27,217 | $ 27,217 |  |
Agilis |  |  |  |
Operating loss carryforwards |  |  |  |
Deferred tax liability on indefinite-lived intangibles acquired |  |  |  | $ 122,000
Federal |  |  |  |
Operating loss carryforwards |  |  |  |
Net operating loss carryforwards | 333,100 |  |  |
Operating loss carryforwards limited by IRC Section 382 | 231,500 |  |  |
Research and development credit carryforwards | 29,000 |  |  |
Operating loss carryforwards, not subject to expiration | 169,200 |  |  |
Operating loss carryforwards, subject to expiration | 62,300 |  |  |
Net operating loss carryforwards limited by IRC Section 382 utilized | 11,400 |  | $ 97,700 |
Operating loss carryforwards for immediate use | 333,100 |  |  |
Operating loss carryforwards in next twelve months | 5,700 |  |  |
Federal | First five years from ownership change |  |  |  |
Operating loss carryforwards |  |  |  |
Annual net operating loss carryforward available as limited by IRC Section 382 | 16,700 |  |  |
Federal | After five years |  |  |  |
Operating loss carryforwards |  |  |  |
Annual net operating loss carryforward available as limited by IRC Section 382 | 5,700 |  |  |
State |  |  |  |
Operating loss carryforwards |  |  |  |
Net operating loss carryforwards | $ 164,900 |  |  |

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