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Stock award plan - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 12 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jun. 08, 2022 | Dec. 31, 2022 | Dec. 31, 2020 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Apr. 30, 2022 | Jun. 30, 2021 | May 31, 2021 | Jan. 31, 2020
Stock option plan |  |  |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  | $ 110,333 | $ 103,513 | $ 70,325 |  |  |  |
Unrecognized compensation cost |  | $ 176,100 |  | $ 176,100 |  |  |  |  |  |
Weighted average remaining service period for recognition of unrecognized compensation cost |  |  |  | 2 years 2 months 8 days |  |  |  |  |  |
Stock option |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Granted (in shares) |  |  |  | 1,685,435 | 2,487,234 | 2,777,975 |  |  |  |
Forfeited (in shares) |  |  |  | 458,737 | 742,458 | 889,785 |  |  |  |
Expected dividend yield (as a percent) |  |  |  | 0.00% | 0.00% | 0.00% |  |  |  |
Weighted average grant date fair value (in dollars per share) |  |  |  | $ 23.54 | $ 43.05 | $ 36.94 |  |  |  |
Stock option | Maximum |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Vesting period |  |  |  | 4 years |  |  |  |  |  |
Employee Stock Purchase Plan |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Number of shares authorized (in shares) |  |  |  |  |  |  |  | 2,000,000 | 1,000,000 |
Award requisite service period |  |  |  | 6 months |  |  |  |  |  |
Share-based compensation expense |  |  |  | $ 2,400 |  |  |  |  |  |
Employee Stock Purchase Plan | Minimum |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Purchase price of common stock, percent |  |  |  | 85.00% |  |  |  |  |  |
Employee stock purchase plan, voting percentage limit |  |  |  | 5.00% |  |  |  |  |  |
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Number of shares available for issuance |  | 0 |  | 0 |  |  |  |  |  |
Amended 2013 LTIP |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Number of additional shares authorized (in shares) | 8,475,000 |  |  |  |  |  |  |  |  |
Amended 2013 LTIP | Maximum |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Number of shares authorized (in shares) | 16,724,212 |  |  |  |  |  |  |  |  |
2013 Long Term Incentive Plan |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Number of shares available for issuance |  | 9,126,463 |  | 9,126,463 |  |  |  |  |  |
2020 Inducement Stock Incentive Plan |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Number of shares available for issuance |  | 1,820,565 |  | 1,820,565 |  |  |  |  |  |
Number of additional shares authorized (in shares) |  |  | 1,000,000 |  |  |  |  |  |  |
2020 Inducement Stock Incentive Plan | Maximum |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Number of shares authorized (in shares) |  |  |  |  |  |  |  |  |  | 1,000,000
2020 Inducement Stock Incentive Plan | Common stock | Maximum |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Number of shares authorized (in shares) |  |  |  |  |  |  | 1,300,000 |  |  |
Number of additional shares authorized (in shares) |  | 1,700,000 |  |  |  |  |  |  |  |
2020 Inducement Stock Incentive Plan | Stock option |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Granted (in shares) |  |  |  |  | 104,385 |  |  |  |  |
Forfeited (in shares) |  |  |  |  | 237,700 |  |  |  |  |
Stockholder's specified ownership percentage |  | 10.00% |  | 10.00% |  |  |  |  |  |
Expiration period |  |  |  | 10 years |  |  |  |  |  |
Granted (in dollars per share) |  |  |  |  | $ 42.02 |  |  |  |  |
2020 Inducement Stock Incentive Plan | Stock option | Minimum |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date |  | 100.00% |  | 100.00% |  |  |  |  |  |
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date |  | 110.00% |  | 110.00% |  |  |  |  |  |
2020 Inducement Stock Incentive Plan | Restricted stock units |  |  |  |  |  |  |  |  |  |
Stock option plan |  |  |  |  |  |  |  |  |  |
Granted (in shares) |  |  |  |  | 43,800 |  |  |  |  |
Forfeited (in shares) |  |  |  |  | 26,336 |  |  |  |  |

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2)(iii) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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