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v3.22.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities |  |  |
Net loss | $ (559,017) | $ (523,901) | $ (438,160)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 128,836 | 64,134 | 43,490
Non-cash operating lease expense | 9,884 | 7,386 | 6,084
Non-cash finance lease amortization expense |  |  | 41,382
Non-cash royalty revenue related to sale of future royalties | (48,738) | (23,460) | (2,055)
Non-cash interest expense on liability related to sale of future royalties | 72,639 | 77,683 | 31,817
Intangible asset impairment | 33,384 |  |
Change in valuation of deferred and contingent consideration | (25,900) | (500) | 23,280
Settlement of deferred and contingent consideration |  |  | 10,613
Non-cash stock consideration, acquisition |  |  | 42,869
Unrealized loss (gain) on ClearPoint Equity Investments | 3,560 | 6,078 | (14,310)
Unrealized loss (gain) on ClearPoint convertible debt security | 5,740 | 8,281 | (19,252)
Unrealized loss (gain) on marketable securities - equity investments | 7,992 | (1,673) |
Disposal of asset | 80 |  | 16
Deferred income taxes | (34,276) | 377 | 5,872
Amortization of premiums on investments, net | 1,713 | 5,299 | 409
Amortization of debt issuance costs | 1,901 | 1,848 | 1,020
Share-based compensation expense | 110,333 | 103,513 | 70,325
Non-cash interest expense |  |  | 22,598
Unrealized foreign currency transaction losses, net | 13,263 | 47,391 | (56,980)
Non cash foreign currency remeasurement loss on intercompany loan | 16,887 |  |
Changes in operating assets and liabilities: |  |  |
Inventory, net | (6,668) | 1,800 | 1,841
Prepaid expenses and other current assets | (51,621) | (15,310) | (12,621)
Trade and royalty receivables, net | (48,468) | (44,991) | (10,483)
Deposits and other assets | (2,913) | (232) | (662)
Accounts payable and accrued expenses | 27,542 | 45,659 | 71,963
Other liabilities | (4,558) | (6,704) | (3,930)
Deferred revenue | 1,351 | (4,010) | (8,032)
Payments on contingent consideration | (9,600) |  | (1,165)
Net cash used in operating activities | (356,654) | (251,332) | (194,071)
Cash flows from investing activities |  |  |
Purchases of fixed assets | (32,016) | (28,213) | (17,843)
Purchases of marketable securities - available for sale | (52,764) | (333,148) | (1,439,665)
Purchase of convertible debt security |  |  | (10,000)
Purchases of marketable securities - equity investments | (22,787) | (210,018) |
Sale and redemption of marketable securities- available for sale | 405,234 | 843,498 | 944,094
Sale and redemption of marketable securities - equity investments | 112,958 | 4,281 |
Acquisition of product rights and licenses | (120,444) | (57,118) | (38,134)
Purchase of equity investment in ClearPoint |  | (100) |
Net cash provided by (used in) investing activities | 290,181 | 219,182 | (561,548)
Cash flows from financing activities |  |  |
Proceeds from exercise of options | 14,632 | 17,309 | 70,179
Termination and exit fees related to payoff of secured term loan |  |  | (597)
Net proceeds from public offerings |  |  | 28,092
Debt issuance costs related to secured term loan | (11,454) |  |
Proceeds from issuance of senior secured term loan | 300,000 |  |
Repayment of Convertible Notes | (150,000) |  | (28,333)
Payments on deferred and contingent consideration obligation | (40,400) |  | (38,100)
Proceeds from employee stock purchase plan | 6,450 | 5,792 | 5,303
Payment of finance lease principal | (1,276) | (2,224) | (17,829)
Proceeds from stock purchase agreement | 50,000 |  |
Cash consideration received from Royalty Purchase Agreement |  |  | 650,000
Net cash provided by financing activities | 167,952 | 20,877 | 668,715
Effect of exchange rate changes on cash | (2,772) | (7,821) | 7,688
Net decrease in cash and cash equivalents | 98,707 | (19,094) | (79,216)
Cash and cash equivalents, and restricted cash beginning of period | 197,218 | 216,312 | 295,528
Cash and cash equivalents, and restricted cash end of period | 295,925 | 197,218 | 216,312
Supplemental disclosure of cash information |  |  |
Cash paid for interest | 18,463 | 9,588 | 9,802
Cash paid for income taxes | 4,922 | 7,708 | 26,397
Supplemental disclosure of non-cash investing and financing activity |  |  |
Unrealized gain (loss) on marketable securities, net of tax | 108 | (2,502) | 1,145
Right-of-use assets obtained in exchange for operating lease obligations | 35,817 | 645 | 76,811
Right-of-use assets obtained in exchange for finance lease obligations |  |  | 41,382
Acquisition of product rights and licenses | 33,239 | $ 22,294 | 14,191
Issuance of common stock related to rights exchange |  |  | 150,528
Debt issuance costs related to senior secured term loan | 159 |  |
Capital expenditures unpaid at the end of period | $ 308 |  | $ 1,060

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- Definition Amount of cash outflow to acquire investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3151-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI https://asc.fasb.org/extlink&oid=124260329&loc=d3e26853-111562 + Details
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- Definition The cash outflow associated with the purchase of or advances to an equity method investments, which are investments in joint ventures and entities in which the entity has an equity ownership interest normally of 20 to 50 percent and exercises significant influence. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3213-108585 + Details
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- Definition The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3213-108585 + Details
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- Definition Amount of cash outflow for purchase of marketable security. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI https://asc.fasb.org/extlink&oid=124260329&loc=d3e26853-111562 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the amount received from entity's raising of capital via private rather than public placement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 + Details
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- Definition The cash inflow from amounts received from issuance of long-term debt that is wholly or partially secured by collateral. Excludes proceeds from tax exempt secured debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period. + References No definition available. + Details
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- Definition Amount of cash inflow from sale of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI https://asc.fasb.org/extlink&oid=124260329&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3151-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3179-108585 + Details
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- Definition Amount of cash inflow from exercise of option under share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=128089324&loc=SL79508275-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 + Details
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- Definition The cash outflow from the repayment of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3291-108585 + Details
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- Definition Amount of increase in right-of-use asset obtained in exchange for finance lease liability. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 55 -Paragraph 53 -URI https://asc.fasb.org/extlink&oid=123414884&loc=SL77918982-209971 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 50 -Paragraph 4 -Subparagraph (g)(2) -URI https://asc.fasb.org/extlink&oid=128292326&loc=SL77918686-209980 + Details
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