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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - Commitments - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Jul. 31, 2022 | Dec. 31, 2022 | Dec. 31, 2021
Development and Regulatory Milestones |  |  |
Changes in the fair value of warrant liability and SARs liability |  |  |
Beginning Balance |  | $ 139,300 | $ 139,200
Change in fair value |  | (6,800) | 100
Payments | $ (50,000) | (50,000) |
Ending Balance |  | 82,500 | 139,300
Net Sales Milestones and Royalties |  |  |
Changes in the fair value of warrant liability and SARs liability |  |  |
Beginning Balance |  | 100,600 | 101,200
Change in fair value |  | (19,100) | (600)
Ending Balance |  | $ 81,500 | $ 100,600

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- Definition Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=126976982&loc=d3e19207-110258 + Details
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- Definition Amount of purchases, (sales), issuances and (settlements) of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI https://asc.fasb.org/extlink&oid=126976982&loc=d3e19207-110258 + Details
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