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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
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Payables and Accruals [Abstract] |  |
Employee compensation, benefits, and related accruals | $ 62,669 | $ 55,733
Income tax payable | 4,712 | 1,287
Consulting and contracted research | 38,882 | 26,434
Professional fees | 3,093 | 3,547
Sales allowance | 63,787 | 61,662
Sales rebates | 67,355 | 68,770
Royalties | 40,546 | 35,679
Accounts payable | 27,268 | 23,033
Other | 12,054 | 12,639
Accounts payable and accrued expenses | $ 320,366 | $ 288,784

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