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Income taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Deferred tax assets: |  |
Accrued expense | $ 2,124 | $ 8,208
Amortization | 52,532 | 87,998
Federal tax credits | 174,802 | 142,595
State tax credits | 9,787 | 8,054
Federal net operating losses | 69,957 | 76,589
State net operating losses | 10,316 | 9,159
Foreign net operating losses | 4,837 | 3,316
Capitalized research and development costs | 110,219 | 241
Share based compensation and other | 27,054 | 15,273
Liability for sale of future royalties | 185,589 | 148,503
Noncash interest expense | 30,160 | 26,040
Other comprehensive loss | (719) | 143
Total gross deferred tax assets | 676,658 | 526,119
Less valuation allowance | (672,172) | (525,570)
Total deferred tax assets, net of valuation allowance | 4,486 | 549
Deferred tax liabilities: |  |
Depreciation | (4,486) | (549)
Indefinite lived intangible | (102,834) | (137,110)
Total gross deferred tax liabilities | (107,320) | (137,659)
Net deferred tax assets (liabilities) | $ (102,834) | $ (137,110)

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