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Fair value of financial instruments and investments - Hierarchy (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - available for sale | $ 22,610 | $ 376,685
Contingent consideration payable | 164,000 | 239,900
Transfers from Level 1 to Level 2 | 0 | 0
Transfers from Level 2 to Level 1 | 0 | 0
Recurring basis |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - available for sale | 22,610 | 376,685
Marketable securities - equity investments | 108,261 | 206,973
ClearPoint Equity Investments | 10,965 | 14,525
ClearPoint convertible debt security | 15,231 | 20,971
Recurring basis | Quoted prices in active markets for identical assets (Level 1) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - equity investments | 108,261 | 206,973
ClearPoint Equity Investments | 10,965 | 14,525
Recurring basis | Significant other observable inputs (Level 2) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Marketable securities - available for sale | 22,610 | 376,685
ClearPoint convertible debt security | 15,231 | 20,971
Recurring basis | Development and Regulatory Milestones |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 82,500 | 139,300
Recurring basis | Development and Regulatory Milestones | Significant unobservable inputs (Level 3) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 82,500 | 139,300
Recurring basis | Net Sales Milestones and Royalties |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | 81,500 | 100,600
Recurring basis | Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) |  |
Financial assets and liabilities measured at fair value on recurring basis |  |
Contingent consideration payable | $ 81,500 | $ 100,600

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